2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. Alectinib analog

Alectinib analog  (Synonyms: CH5424802 analog; RO5424802 analog; RG7853 analog)

目录号: HY-W814315
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Alectinib analog (CH5424802 analog)是一种选择性ALK抑制剂，具有阻断耐药门控突变的活性。Alectinib analog的合成优化使其能与特定肽结合，以提高靶向抗癌细胞的能力。Alectinib analog在抗增殖方面表现出低微摩尔的IC50值，显示出良好的细胞毒性效果。Alectinib analog的抑制活性与其稳定性和活性成分的释放密切相关。Alectinib analog在体内斑马鱼模型中展示了抑制血管间隔长度或宽度的能力。

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Alectinib analog Chemical Structure

Alectinib analog Chemical Structure

CAS No. : 1256577-71-5

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Alectinib analog 相关抗体

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  • 生物活性

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生物活性

Alectinib analog (CH5424802 analog) is a selective ALK inhibitor with activity in blocking resistance gating mutations. The synthetic optimization of alectinib analog allows it to be combined with specific peptides to improve the ability to target cancer cells. Alectinib analog exhibits low micromolar IC50 values in antiproliferation and shows good cytotoxic effects. The inhibitory activity of alectinib analog is closely related to its stability and release of active ingredients. Alectinib analog demonstrated the ability to inhibit vascular septal length or width in an in vivo zebrafish model[1].

分子量

454.56

Formula

C28H30N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Alectinib analog 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Alectinib1256577-71-5CH5424802RO5424802RG7853CH 5424802CH-5424802RO 5424802RO-5424802RG 7853RG-7853Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Inhibitorinhibitorinhibit

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