2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. ALK5-IN-29

ALK5-IN-29 是一种选择性的激活素受体样激酶 (ALK) 抑制剂。 ALK5-IN-29 可以抑制激活素受体样激酶的活性，IC50 值 ≤10 nM。AALK5-IN-29 还具有抑制肿瘤生长的作用，可用于癌症等增殖性疾病的研究。

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ALK5-IN-29 Chemical Structure

ALK5-IN-29 Chemical Structure

CAS No. : 2785430-85-3

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ALK5-IN-29 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALK5-IN-29 is an selective activin receptor-like kinase (ALK) inhibitor. ALK5-IN-29 can inhibit the activity of ALK5 with an IC50 value of ≤10 nM. ALK5-IN-29 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer[1].

IC50 & Target

IC50: ≤10 nM (ALK5/2); ≤100 nM (RD-SMAD receptor)[1]
体外研究
(In Vitro)

ALK5-IN-29 (EX-06) has kinase inhibition of ALK5 with an IC50 value of ≤10 nM[1].
ALK5-IN-29 has kinase selectivity of ALK2/ALK5 with an IC50 value of ≤10 nM[1].
ALK5-IN-29 shows TGFB-RI inhibition (RD-SMAD receptor activity) with an IC50 value of ≤100 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ALK5-IN-29 相关抗体:
分子量

444.51

Formula

C24H25FN8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALK5-IN-29 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK5-IN-292785430-85-3Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246activin receptor-like kinase (ALK)ALK2ALK5tumor growthproliferative diseasescancerInhibitorinhibitorinhibit

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