2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. ALKBH5-IN-4

ALKBH5-IN-4 (compound 3) 是一种抑制 RNA m6A 脱甲基酶 ALKBH5 的抑制剂， IC50为 0.84 μM。ALKBH5-IN-4 对白血病细胞显示抑制作用。

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ALKBH5-IN-4 Chemical Structure

ALKBH5-IN-4 Chemical Structure

CAS No. : 37510-29-5

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ALKBH5-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALKBH5-IN-4 (compound 3) is a RNA m6A demethylase ALKBH5 inhibitor with an IC50 of 0.84 μM. ALKBH5-IN-4 shows inhibitory effect on leukemia cells[1].

体外研究
(In Vitro)

ALKBH5-IN-4 (1-100 μM, 0-48 h) 抑制 HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 细胞增殖的 IC50 分别为 >50, 1.38, 11.9, 47.8, 16.5, >50 μM [1]。
ALKBH5-IN-4 (1-100 μM, 2 h) 抑制 RNA m6A 脱甲基酶 ALKBH5 的 IC50 为 0.84 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ALKBH5-IN-4 相关抗体:

Cell Viability Assay

Cell Line: HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells
Concentration: 1, 10, 100 μM
Incubation Time: 4, 8, 24, 48 h
Result: Inhibited HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells proliferation respectively.
分子量

226.25

Formula

C10H10O4S
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度 & 产品资料
参考文献

ALKBH5-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALKBH5-IN-437510-29-5DNA/RNA SynthesisleukemiaglioblastomaHL-60CCRF-CEMK562Jurkate A-172HEK-293TdemethylaseInhibitorinhibitorinhibit

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