2. Apoptosis
  3. Apoptosis
  4. Allethrin

Allethrin  (Synonyms: 丙烯菊酯)

目录号: HY-B1559 纯度: 98.04%
COA 产品使用指南

摩尔计算器

Allethrin 是一种拟除虫菊酯杀虫剂，是一种主要的驱蚊剂。Allethrin 在大鼠睾丸癌细胞 (LC540) 中诱导氧化应激、细胞凋亡 (apoptosis) 和钙释放。Allethrin 还诱导 BCL-2、caspase-3 激活和细胞内钙的释放。

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Allethrin Chemical Structure

Allethrin Chemical Structure

CAS No. : 584-79-2

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规格 价格 是否有货 数量
5 mg ￥600
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10 mg ￥960
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Other Forms of Allethrin:

Allethrin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Allethrin, a pyrethroid insecticide is a major mosquito repellent agent. Allethrin induces oxidative stress, apoptosis and calcium release in rat testicular carcinoma cells (LC540). Allethrin induces BCL-2, caspase-3 activation and release of intracellular calcium[1].

体外研究
(In Vitro)

Allethrin (0.001-250 μM) induces cytotoxicity and oxidative stress. Allethrin is cytotoxic to isolated Leydig cells and testicular cancer cells. Cytotoxicity is due to free radical generation and altered antioxidant status[1].
Morphological analyses of LC540 cells treated with Allethrin (125 μM) reveals the presence of apoptotic bodies[1].
Allethrin (125 μM) induces BCL-2, caspase-3 activation and release of intracellular calcium[1].
Allethrin (IC50≈85 μM) is toxic to human corneal epithelial (HCE) cells causing death through mitochondrial pathway[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Allethrin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: LC540 cells (derived from rat Leydig cell tumor)
Concentration: 0.001-250 μM
Incubation Time: 24 hours
Result: At low concentrations did not display appreciable cell killing activity up to 50 μM when incubated for 24 h.
At concentrations above 100 μM, cell killing was observed. Based on the results obtained, the IC50 was 125 μM.

Apoptosis Analysis[1]

Cell Line: LC540 cells
Concentration: 125 μM
Incubation Time: 24 hours
Result: Revealed the presence of apoptotic bodies. The percentage of cells displaying early apoptotic features increased significantly.

Western Blot Analysis[1]

Cell Line: LC540 cells
Concentration: 125 μM
Incubation Time: 0, 3, 6, 9, 12, 24 hours
Result: BCL-2, pro-Caspase-3 and PARP-1 protein expression decreased significantly with an increase in cleaved PARP-1 levels.
体内研究
(In Vivo)

Adult male rats are treated orally with Allethrin (25, 50, 100, and 150 mg/kg; every day for 60 days). Lipid peroxidation is increased in the caput, cauda, and testes. Nitric oxide production is increased in the caput, but unaltered in the cauda and testes. The activities of catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), and superoxide dismutase (SOD) are decreased in the caput and cauda[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats aged 90 days[3]
Dosage: 25, 50, 100, and 150 mg/kg
Administration: Orally administered every day for 60 days
Result: Increased levels of LPO products were observed in the caput, cauda, and testes of allethrin treated rats.
In the caput, increased levels of NO was observed at all the doses tested, when compared with the vehicle treated control.
Significant increase in catalase activity was observed in the cauda obtained from 50, 100, and 150 mg/kg.
GPx activity was significantly increased in the caput obtained from 150 mg/kg treated rats. In the cauda, it was found to be increased significantly in the 50 and 100 mg/kg treated groups. In contrast, the activity of GPx activity was significantly decreased in the testes of rats treated with 150 mg/kg.
GST activity was found to be increased significantly in a dose dependent manner in the caput and cauda of allethrin treated rats.
In the caput, significant increase in the activity of SOD was observed in the 150 mg/kg body treated rats. In the cauda and testes, treatment resulted in increase of SOD activity at all the doses tested.
分子量

302.41

Formula

C19H26O3
CAS 号
性状

液体（密度：1.01 g/cm3）

颜色

Colorless to light yellow

中文名称

丙烯菊酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (330.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3068 mL 16.5338 mL 33.0677 mL
5 mM 0.6614 mL 3.3068 mL 6.6135 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Allethrin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3068 mL 16.5338 mL 33.0677 mL 82.6692 mL
5 mM 0.6614 mL 3.3068 mL 6.6135 mL 16.5338 mL
10 mM 0.3307 mL 1.6534 mL 3.3068 mL 8.2669 mL
15 mM 0.2205 mL 1.1023 mL 2.2045 mL 5.5113 mL
20 mM 0.1653 mL 0.8267 mL 1.6534 mL 4.1335 mL
25 mM 0.1323 mL 0.6614 mL 1.3227 mL 3.3068 mL
30 mM 0.1102 mL 0.5511 mL 1.1023 mL 2.7556 mL
40 mM 0.0827 mL 0.4133 mL 0.8267 mL 2.0667 mL
50 mM 0.0661 mL 0.3307 mL 0.6614 mL 1.6534 mL
60 mM 0.0551 mL 0.2756 mL 0.5511 mL 1.3778 mL
80 mM 0.0413 mL 0.2067 mL 0.4133 mL 1.0334 mL
100 mM 0.0331 mL 0.1653 mL 0.3307 mL 0.8267 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Allethrin584-79-2丙烯菊酯ApoptosisPyrethroidinsecticidemosquitorepellentoxidativestressapoptosiscalciumreleaseepididymistestisspermmaturationInhibitorinhibitorinhibit

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