2. Metabolic Enzyme/Protease
  3. Elastase
  4. Alvelestat tosylate

Alvelestat tosylate  (Synonyms: AZD9668 tosylate)

目录号: HY-15651A
产品使用指南 技术支持

Alvelestat (AZD9668) 是一种口服生物利用度，亲和性和选择性的中性粒细胞弹性蛋白酶 (NE) 抑制剂，其 pIC50 值为 7.9 nM，Ki 值为 9.4 nM，Kd 值为 9.5 nM。

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Alvelestat tosylate Chemical Structure

Alvelestat tosylate Chemical Structure

CAS No. : 1240425-05-1

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Alvelestat tosylate 的其他形式现货产品:

Customer Review

Other Forms of Alvelestat tosylate:

Alvelestat tosylate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1].

IC50 & Target

pIC: 7.9 nM; Ki: 9.4 nM; Kd: 9.5 nM (neutrophil elastas)[1]
体外研究
(In Vitro)

Alvelestat (20 μg/mL; 16 hours; HBE and A549 cells) treatment decreases cells death and decreases the levels of IL-1β, IL-6, and TNF-α in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Alvelestat tosylate 相关抗体:
Clinical Trial
分子量

717.74

Formula

C32H30F3N5O7S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Alvelestat tosylate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alvelestat1240425-05-1AZD9668AZD 9668AZD-9668Elastaseorally bioavailableaffinityselectiveneutrophil elastaseInhibitorinhibitorinhibit

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