2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. AM-4668

AM-4668 是一种 GPR40 激动剂，用于2 型糖尿病研究。在 A9 细胞中和 CHO 细胞，激活 GPR40 的 EC50 分别为 3.6 nM 和 36 nM。

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AM-4668 Chemical Structure

AM-4668 Chemical Structure

CAS No. : 1011531-27-3

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规格 价格 是否有货 数量
1 mg ￥3360
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AM-4668 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM-4668 is a GPR40 agonist for type 2 diabetes. EC50s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively[1].

IC50 & Target

EC50: 3.6 nM (GPR40, in A9 cells), 36 nM (GPR40, in CHO cells)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A9 EC50
3.6 nM
Compound: 10, AM-4668
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
[PMID: 24900872]
CHO EC50
36 nM
Compound: 10, AM-4668
Agonist activity at human GPR40 expressed in CHO cells by aequorin assay
Agonist activity at human GPR40 expressed in CHO cells by aequorin assay
[PMID: 24900872]
分子量

488.48

Formula

C24H19F3N2O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (261 KB)

产品使用指南 (1538 KB)
参考文献

AM-4668 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-46681011531-27-3AM4668AM 4668Free Fatty Acid ReceptorFFARInhibitorinhibitorinhibit

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产品名称：
AM-4668
目录号：
HY-12585
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