2. Apoptosis
  3. MDM-2/p53
  4. AM-7209

AM-7209 是一种有效的选择性 MDM2-p53 相互作用抑制剂，Kd 为 38 pM。AM-7209 抑制 MDM2 扩增的 SJSA-1 骨肉瘤细胞系，IC50 为 1.6 nM。AM-7209 显示出抗肿瘤活性。

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AM-7209 Chemical Structure

AM-7209 Chemical Structure

CAS No. : 1623432-51-8

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AM-7209 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a Kd of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC50 of 1.6 nM. AM-7209 shows antitumor activities[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
> 25 μM
Compound: 25, AM-7209
Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay
Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay
[PMID: 25384157]
HCT-116 IC50
2 nM
Compound: 25, AM-7209
Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay
Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay
[PMID: 25384157]
SJSA-1 ED50
2.6 mg/kg
Compound: 25, AM-7209
Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days
Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days
[PMID: 25384157]
分子量

747.70

Formula

C37H41Cl2FN2O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AM-7209 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-72091623432-51-8AM7209AM 7209MDM-2/p53MDM2-p53 interaction inhibitorantitumor activitiesInhibitorinhibitorinhibit

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