2. Apoptosis
  3. MDM-2/p53
  4. AM-8553

AM-8553 是一种 MDM2/p53 抑制剂 (KD: 对 MDM2 为 0.4 nM)。AM-8553 具有抗肿瘤活性。

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AM-8553 Chemical Structure

AM-8553 Chemical Structure

CAS No. : 1352064-70-0

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AM-8553 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM-8553 is a MDM2/p53 inhibitor (KD: 0.4 nM for MDM2). AM-8553 has anti-tumor activity[1]

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
> 25 μM
Compound: 29, AM-8553
Antiproliferative activity against p53 deficient human HCT116 cells assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry
Antiproliferative activity against p53 deficient human HCT116 cells assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry
[PMID: 22524527]
HCT-116 IC50
0.2 μM
Compound: 29, AM-8553
Antiproliferative activity against human HCT116 cells expressing wild type p53 assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry
Antiproliferative activity against human HCT116 cells expressing wild type p53 assessed as reduction in BrdU incorporation after 16 hrs by Flow cytometry
[PMID: 22524527]
SJSA-1 IC50
0.068 μM
Compound: 29, AM-8553
Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation assay in presence of 10% human serum
Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation assay in presence of 10% human serum
[PMID: 22524527]
SJSA-1 IC50
0.073 μM
Compound: 1, AM-8553
Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation-based HCS assay in presence of 10% human serum
Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation-based HCS assay in presence of 10% human serum
[PMID: 25147610]
SJSA-1 IC50
0.76 μM
Compound: 29, AM-8553
Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum
Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum
[PMID: 22524527]
SJSA-1 IC50
72 nM
Compound: 1, AM-8553
Antiproliferative activity against human SJSA1 cells assessed as inhibition of EdU incorporation after 1 hr by Click-iT EdU HCS assay in presence of 10% human serum
Antiproliferative activity against human SJSA1 cells assessed as inhibition of EdU incorporation after 1 hr by Click-iT EdU HCS assay in presence of 10% human serum
[PMID: 24456472]
SJSA-1 IC50
760 nM
Compound: 1, AM-8553
Antiproliferative activity against human SJSA1 cells assessed as induction of p21 gene level by qRT-PCR assay in presence of 10% human serum
Antiproliferative activity against human SJSA1 cells assessed as induction of p21 gene level by qRT-PCR assay in presence of 10% human serum
[PMID: 24456472]
SJSA-1 ED50
78 mg/kg
Compound: 29, AM-8553
Antitumor activity against human SJSA1 cells xenografted in po dosed athymic nude mouse assessed as tumor growth inhibition administered qd after 14 days
Antitumor activity against human SJSA1 cells xenografted in po dosed athymic nude mouse assessed as tumor growth inhibition administered qd after 14 days
[PMID: 22524527]
分子量

478.41

Formula

C25H29Cl2NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AM-8553 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-85531352064-70-0AM8553AM 8553MDM-2/p53SJSA-1 xenograft tumorMDM2/p53Inhibitorinhibitorinhibit

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