1. Immunology/Inflammation Apoptosis
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  3. Aminoguanidine

Aminoguanidine  (Synonyms: 氨基胍; Pimagedine; GER-11(free base) ; Aminoguanidinium)

目录号: HY-B1041A
产品使用指南

Aminoguanidine (Pimagedine hydrochloride) 是二胺氧化酶和一氧化氮合酶抑制剂。 Aminoguanidine 对阿霉素 (HY-15142) 诱导的细胞凋亡具有剂量依赖性的抑制作用。Aminoguanidine 具有抗氧化作用。Aminoguanidine 可用于糖尿病肾病研究。

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Aminoguanidine Chemical Structure

Aminoguanidine Chemical Structure

CAS No. : 79-17-4

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Aminoguanidine 的其他形式现货产品:

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  • 生物活性

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生物活性

Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research[1][2][3][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DLD-1 IC50
> 1000 μM
Compound: 4
Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells
Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells
[PMID: 12620067]
DLD-1 IC50
4.5 μM
Compound: 4
Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
[PMID: 11327580]
DLD-1 IC50
54 μM
Compound: 1
Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
10.1016/0960-894X(95)00273-V
HUVEC IC50
72 μM
Compound: 4
Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
[PMID: 11327580]
J774 IC50
9 μM
Compound: 1
Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells
Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells
10.1016/0960-894X(95)00273-V
RAW264.7 CC50
> 100 μM
Compound: Aminoguanidine
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay
[PMID: 22148193]
RAW264.7 IC50
0.021 mM
Compound: AG
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
[PMID: 18986199]
RAW264.7 IC50
0.05 μM
Compound: AG
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs
[PMID: 20192236]
RAW264.7 IC50
0.2 μM
Compound: AG
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
[PMID: 21924800]
RAW264.7 IC50
0.23 μM
Compound: AG
Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
[PMID: 25176187]
RAW264.7 IC50
1.8 μM
Compound: Aminoguanidine
Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
[PMID: 33454546]
RAW264.7 IC50
11.91 μM
Compound: AG
Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method
Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method
[PMID: 26280922]
RAW264.7 IC50
16.3 μM
Compound: AG
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay
[PMID: 11809076]
RAW264.7 IC50
16.6 μM
Compound: AG
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 24035341]
RAW264.7 IC50
16.6 μM
Compound: aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 23743282]
RAW264.7 IC50
16.9 μM
Compound: Aminoguanidine
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
[PMID: 24813739]
RAW264.7 IC50
17.5 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 22079762]
RAW264.7 IC50
17.5 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay
[PMID: 29280630]
RAW264.7 IC50
18.4 μM
Compound: Aminoguanidine
Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay
Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay
[PMID: 27634197]
RAW264.7 IC50
18.7 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method
[PMID: 27246615]
RAW264.7 IC50
18.7 μM
Compound: Aminoguanidine
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay
[PMID: 26702644]
RAW264.7 IC50
18.7 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
[PMID: 25592708]
RAW264.7 IC50
18.7 μM
Compound: Aminoguanidine
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay
[PMID: 33476145]
RAW264.7 IC50
18.7 μM
Compound: AG
Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry
Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry
[PMID: 23454014]
RAW264.7 IC50
19.9 μM
Compound: Aminoguanidine
Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay
[PMID: 31860303]
RAW264.7 IC50
2.7 μM
Compound: AG
Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
[PMID: 20515062]
RAW264.7 IC50
20.6 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
[PMID: 26073007]
RAW264.7 IC50
20.6 μM
Compound: AG
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction
[PMID: 26331882]
RAW264.7 IC50
20.7 μM
Compound: Aminoguanidine
Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
[PMID: 33667099]
RAW264.7 IC50
21.4 μM
Compound: aminoguanidine
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
[PMID: 24963714]
RAW264.7 IC50
21.7 μM
Compound: Aminoguanidine
Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay
Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay
[PMID: 31244142]
RAW264.7 IC50
22.3 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis
[PMID: 24597849]
RAW264.7 IC50
22.6 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
[PMID: 22325804]
RAW264.7 IC50
24.2 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis
[PMID: 27865705]
RAW264.7 IC50
24.7 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay
[PMID: 27976895]
RAW264.7 IC50
25.5 μM
Compound: Aminoguanidine
Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay
[PMID: 31642320]
RAW264.7 IC50
26.55 μM
Compound: Aminoguanidine
Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs
Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs
[PMID: 21846089]
RAW264.7 IC50
28 μM
Compound: AG
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay
[PMID: 19113968]
RAW264.7 IC50
28.47 μM
Compound: Aminoguanidine
Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method
Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method
[PMID: 22148193]
RAW264.7 IC50
32.17 μM
Compound: aminoguanidine
Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs
Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs
[PMID: 17338565]
RAW264.7 IC50
32.2 μM
Compound: Aminoguanidine
Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs
Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs
[PMID: 21273070]
RAW264.7 IC50
4.06 μM
Compound: AG
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method
[PMID: 14510600]
RAW264.7 IC50
4.6 μM
Compound: aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA
[PMID: 21090796]
RAW264.7 IC50
43.3 μM
Compound: AG
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method
[PMID: 24996142]
RAW264.7 IC50
6.5 μM
Compound: Aminoguanidine
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay
[PMID: 22691179]
RAW264.7 IC50
7.29 μM
Compound: Aminoguanidine
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis
[PMID: 25703295]
RAW264.7 IC50
7.9 μM
Compound: Aminoguanidine
Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
[PMID: 21894898]
RAW264.7 IC50
8.68 μM
Compound: AG
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control
[PMID: 24974350]
分子量

74.09

Formula

CH6N4

CAS 号
中文名称

氨基胍

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Aminoguanidine
目录号:
HY-B1041A
需求量: