2. Academic Validation
  3. Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity

Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity

  • J Nat Prod. 2011 Dec 27;74(12):2489-96. doi: 10.1021/np100874f.
Su-Ling Wong 1,  Hsun-Shuo Chang,  Guei-Jane Wang,  Michael Y Chiang,  Hung-Yi Huang,  Chu-Huang Chen,  Shiow-Chwen Tsai,  Chu-Hung Lin,  Ih-Sheng Chen
Affiliations

Affiliation

  • 1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
PMID: 22148193 DOI: 10.1021/np100874f
Abstract

Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new β-carboline Alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC₅₀ values of 18.41, 0.30, 19.55, and 10.50 μM, respectively.

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