2. Academic Validation
  3. Pseudoguaianolides and guaianolides from Inula hupehensis as potential anti-inflammatory agents

Pseudoguaianolides and guaianolides from Inula hupehensis as potential anti-inflammatory agents

  • J Nat Prod. 2011 Sep 23;74(9):1881-7. doi: 10.1021/np200319x.
Jiang-Jiang Qin 1,  Jia-Xian Zhu,  Qi Zeng,  Xiang-Rong Cheng,  Yan Zhu,  Shou-De Zhang,  Lei Shan,  Hui-Zi Jin,  Wei-Dong Zhang
Affiliations

Affiliation

  • 1 School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
PMID: 21894898 DOI: 10.1021/np200319x
Abstract

Eight new pseudoguaianolides (1-8), two new guaianolides (9 and 10), and 14 known Sesquiterpenes were isolated from the aerial parts of Inula hupehensis. The structures were elucidated using spectroscopic methods and circular dichroism analysis. All compounds were tested for inhibitory activities against LPS-induced nitric oxide production in RAW264.7 macrophages. Compounds 13 and 22 were found to inhibit nitric oxide production potently, with IC50 values of 0.9 and 0.6 μM, respectively. Preliminary structure-activity relationships for these compounds are proposed.

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