2. Academic Validation
  3. Bioactive 3,4-seco-Triterpenoids from the Fruits of Acanthopanax sessiliflorus

Bioactive 3,4-seco-Triterpenoids from the Fruits of Acanthopanax sessiliflorus

  • J Nat Prod. 2012 Jun 22;75(6):1138-44. doi: 10.1021/np3002173.
Dae-Young Lee 1,  Kyeong-Hwa Seo,  Dong-Sung Lee,  Youn-Chul Kim,  In-Sik Chung,  Gye-Won Kim,  Dae-Sung Cheoi,  Nam-In Baek
Affiliations

Affiliation

  • 1 Graduate School of Biotechnology and Department of Oriental Medicinal Materials and Processing, Kyung Hee University, Yongin 446-701, Republic of Korea.
PMID: 22691179 DOI: 10.1021/np3002173
Abstract

Eight new 3,4-seco-lupane Triterpenes and glycosides, acanthosessiligenins I and II (1, 3) and acanthosessiliosides A-F (2, 4-8), as well as six known 3,4-seco-lupane Triterpenes (9-14) were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures of 1-8 were determined by spectroscopic data interpretation. All isolated compounds were tested for their cytotoxicity against six human Cancer cell lines and their ability to inhibit LPS-induced nitric oxide production in RAW 264.7 macrophages.

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