1. Neuronal Signaling GPCR/G Protein Immunology/Inflammation Membrane Transporter/Ion Channel Protein Tyrosine Kinase/RTK
  2. Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor
  3. Amitriptyline (hydrochloride) (Standard)

Amitriptyline (hydrochloride) (Standard)  (Synonyms: 盐酸阿米替林(标准品) ;盐酸阿密替林(标准品))

目录号: HY-B0527AR 纯度: 99.03%
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Amitriptyline (hydrochloride) (Standard) 是 Amitriptyline (hydrochloride) 的分析标准品。本产品用于研究及分析应用。Amitriptyline hydrochloride 是一种血清素再摄取转运体 (SERT) 和去甲肾上腺素再摄取转运体 (NET) 抑制剂,对人的 SERT 和 NET 作用的 Ki 值分别为 3.45 nM 和 13.3 nM。Amitriptyline hydrochloride 还与多巴胺再摄取转运体 (DAT) 结合,其 Ki 为 2.58 μM。Amitriptyline hydrochloride 也抑制肾上腺素能受体 (adrenergic receptor)、毒蕈碱受体 (muscarinic receptor )、组胺受体 (histamine receptor )、5-羟色胺受体 (5-HT receptor)。Amitriptyline hydrochloride 是一种具有强神经营养活性的 TrkATrkA 受体激动剂。Amitriptyline hydrochloride 具有抗抑郁作用。

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Amitriptyline (hydrochloride) (Standard) Chemical Structure

Amitriptyline (hydrochloride) (Standard) Chemical Structure

CAS No. : 549-18-8

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生物活性

Amitriptyline (hydrochloride) (Standard) is the analytical standard of Amitriptyline (hydrochloride). This product is intended for research and analytical applications. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.

分子量

313.86

Formula

C₂₀H₂₄ClN

CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸阿米替林(标准品) ;盐酸阿密替林(标准品)

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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