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Amonafide dihydrochloride  (Synonyms: AS1413 dihydrochloride)

目录号: HY-10982A
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摩尔计算器

Amonafide dihydrochloride (AS1413 dihydrochloride)是一种拓扑异构酶II (Topo II) 抑制剂和 DNA 插入剂，具有诱导细胞凋亡信号的活性。Amonafide dihydrochloride 能够抑制 Topo II 与 DNA 的结合，进而阻止 DNA 和 RNA 的合成。Amonafide dihydrochloride 在存在P-糖蛋白介导的多药耐药性（MDR）情况下依然保持细胞毒性活性。

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Amonafide dihydrochloride Chemical Structure

Amonafide dihydrochloride Chemical Structure

CAS No. : 150091-68-2

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Amonafide dihydrochloride 的其他形式现货产品:

Other Forms of Amonafide dihydrochloride:

Amonafide dihydrochloride 相关抗体

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  • 生物活性

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生物活性

Amonafide dihydrochloride (AS1413 dihydrochloride) is a topoisomerase II (Topo II) inhibitor and DNA intercalator with activity in inducing apoptotic signaling. Amonafide dihydrochloride can inhibit the binding of Topo II to DNA, thereby preventing the synthesis of DNA and RNA. Amonafide dihydrochloride maintains cytotoxic activity in the presence of P-glycoprotein-mediated multidrug resistance (MDR)[1].

分子量

356.25

Formula

C16H19Cl2N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Amonafide dihydrochloride 相关分类

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Keywords:

Amonafide150091-68-2AS1413AS 1413AS-1413OthersInhibitorinhibitorinhibit

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