2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Amorfrutin B

Amorfrutin B 是一种具有口服活性的高效的天然过氧化物酶体增殖激活受体 γ (PPARγ) 激动剂，Ki 值和 EC50 值分别为 19 nM 和 73 nM。Amorfrutin B 具有降血糖和神经保护活性。

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Amorfrutin B Chemical Structure

Amorfrutin B Chemical Structure

CAS No. : 78916-42-4

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Amorfrutin B 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities[1][2].

体外研究
(In Vitro)

Amorfrutin B (1,5 μM, 6 h) 通过基因甲基化和 miRNA 依赖调控抑制凋亡和自噬过程，保护小鼠脑神经元细胞缺氧/缺血[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amorfrutin B 相关抗体:
体内研究
(In Vivo)

Amorfrutin B (100 mg/kg, 添加在食物中，两周) 可改善胰岛素抵抗小鼠胰岛素敏感性、葡萄糖耐量和血脂浓度[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet mice model[2].
Dosage: 100 mg/kg
Administration: Add to food，2 weeks
Result: Reduced fasting plasma levels of triacylglycerols by 25% and the concentrations of deleterious plasma NEFA by 29%.
分子量

408.53

Formula

C26H32O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Amorfrutin B 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amorfrutin B78916-42-4PPARPeroxisome proliferator-activated receptorsPPARγHFDHypoglycemicNeuroprotectiveInhibitorinhibitorinhibit

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