2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Amorfrutin B

Amorfrutin B 是一种具有口服活性的高效的天然过氧化物酶体增殖激活受体 γ (PPARγ) 激动剂，Ki 值和 EC50 值分别为 19 nM 和 73 nM。Amorfrutin B 具有降血糖和神经保护活性。

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Amorfrutin B Chemical Structure

Amorfrutin B Chemical Structure

CAS No. : 78916-42-4

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Amorfrutin B 相关抗体

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.05 μM
Compound: amorfrutin B
Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay
Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay
[PMID: 23286787]
HEK293 EC50
73 nM
Compound: 2
Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay
Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay
[PMID: 25938459]
HT-29 IC50
20 μM
Compound: 1
Antiproliferative activity against human HT-29 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay
Antiproliferative activity against human HT-29 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay
[PMID: 26731300]
HT-29 IC50
30.5 μM
Compound: 2
Reduction in TNFalpha-induced PPARgamma expression in human HT-29 cells after 48 hrs by Western blotting analysis
Reduction in TNFalpha-induced PPARgamma expression in human HT-29 cells after 48 hrs by Western blotting analysis
[PMID: 25938459]
MCF7 IC50
33 μM
Compound: 1
Antiproliferative activity against human MCF7 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay
Antiproliferative activity against human MCF7 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay
[PMID: 26731300]
PC-3 IC50
32 μM
Compound: 1
Antiproliferative activity against human PC3 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay
Antiproliferative activity against human PC3 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay
[PMID: 26731300]
T84 IC50
13 μM
Compound: 1
Antiproliferative activity against human T84 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay
Antiproliferative activity against human T84 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay
[PMID: 26731300]
体外研究
(In Vitro)

Amorfrutin B (1,5 μM, 6 h) 通过基因甲基化和 miRNA 依赖调控抑制凋亡和自噬过程，保护小鼠脑神经元细胞缺氧/缺血[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amorfrutin B 相关抗体:
体内研究
(In Vivo)

Amorfrutin B (100 mg/kg, 添加在食物中，两周) 可改善胰岛素抵抗小鼠胰岛素敏感性、葡萄糖耐量和血脂浓度[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet mice model[2].
Dosage: 100 mg/kg
Administration: Add to food，2 weeks
Result: Reduced fasting plasma levels of triacylglycerols by 25% and the concentrations of deleterious plasma NEFA by 29%.
分子量

408.53

Formula

C26H32O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Amorfrutin B 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amorfrutin B78916-42-4PPARPeroxisome proliferator-activated receptorsPPARγHFDHypoglycemicNeuroprotectiveInhibitorinhibitorinhibit

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