2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. AMPA receptor modulator-4

AMPA receptor modulator-4 是一种 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD)，是口服有效的 AMPA 受体 (AMPAR PAM) 的正变构调节剂。AMPA receptor modulator-4 可以透过血脑屏障。AMPA receptor modulator-4 可提高小鼠的认知能力并改善工作记忆能力。

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AMPA receptor modulator-4 Chemical Structure

AMPA receptor modulator-4 Chemical Structure

CAS No. : 2917551-59-6

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AMPA receptor modulator-4 相关抗体

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). AMPA receptor modulator-4 can cross the blood-brain barrier. AMPA receptor modulator-4 increases the cognition performance and improves working memory performance in mice[1].

体外研究
(In Vitro)

AMPA receptor modulator-4 (化合物 15e) 对稳定表达 GluA2(Q) 亚基的 HEK293 细胞上 1 mM 谷氨酸诱导的钙内流的 pEC50 为 5.66[1]。
AMPA receptor modulator-4 的 EC2x 为 2.1 μM (FlipR)-1.5 μM (FDSS)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AMPA receptor modulator-4 相关抗体:
体内研究
(In Vivo)

AMPA receptor modulator-4 (10 和 30 mg/kg; 腹腔给药; 一次) 以 10 mg/kg 的剂量增加大鼠 LTP 的持续时间[1]。
AMPA receptor modulator-4 (1 和 3 mg/kg; 口服灌胃) 在三个疗程前 1 小时给药，可以显着提高 CD1 小鼠的认知能力[1]。
AMPA receptor modulator-4 (0.03、0.1 和 0.3 mg/kg; 腹腔注射) 改善 C57BI/6 小鼠的自发交替性能和工作记忆性能[1]。
AMPA receptor modulator-4 (30, 100 mg/kg; 口服灌胃; 一次) 在 NMRI 小鼠中具有非促惊厥作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized rats[1]
Dosage: 10 and 30 mg/kg
Administration: IP; once
Result: Increased the duration of the the Long-Term Potentiation (LTP) at a dose of 10 mg/kg.
分子量

290.74

Formula

C11H12ClFN2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMPA receptor modulator-4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMPA receptor modulator-42917551-59-6AMPA receptor modulator4AMPA receptor modulator 4iGluRIonotropic glutamate receptors3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxideBTDAMPA receptorAMPAR PAMsblood-brain barriercognition performancememory performanceInhibitorinhibitorinhibit

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