Amphotericin B methyl ester hydrochloride  (Synonyms: 盐酸两性霉素B甲酯)

Amphotericin B methyl ester hydrochloride is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester hydrochloride is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester hydrochloride disrupts HIV-1 particle production and potently inhibits HIV-1 replication^[1][2].

Amphotericin B methyl ester hydrochloride inhibits HIV-1 particle production with no significant effect on Gag binding to the plasma membrane, Gag association with lipid rafts, or Gag multimerization^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

974.57

C₄₈H₇₆ClNO₁₇

35375-29-2

盐酸两性霉素B甲酯

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Waheed AA, et al. Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence. J Virol. 2008 Oct;82(19):9776-81.  [Content Brief]

  [2]. Keim GR, et al. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs. ntimicrob Agents Chemother. 1976 Oct;10(4):687-90.  [Content Brief]