2. Immunology/Inflammation Anti-infection
  3. Complement System SARS-CoV
  4. AMY-101 TFA

AMY-101 TFA  (Synonyms: Cp40 TFA)

目录号: HY-P1717A 纯度: 99.89%
COA 产品使用指南

摩尔计算器

AMY-101 TFA (Cp40 TFA) 是补体 C3 的肽类抑制剂 (KD = 0.5 nM)，可抑制非人类灵长类动物自然发生的牙周炎。AMY-101 TFA (Cp40 TFA) 在 COVID-19 重症肺炎合并全身超炎症模型中具有良好的抗炎活性。

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Custom Peptide Synthesis

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AMY-101 TFA Chemical Structure

AMY-101 TFA Chemical Structure

CAS No. : 1789738-04-0

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规格 价格 是否有货 数量
1 mg ￥1200
In-stock
5 mg ￥3200
In-stock
10 mg ￥5000
In-stock
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100 mg   询价  

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Customer Review

Other Forms of AMY-101 TFA:

AMY-101 TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation[1][2].

IC50 & Target

KD: 0.5 nM (C3)[1].
体内研究
(In Vivo)

AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis[1].
AMY-101 can induce a long-lasting anti-inflammatory effect[1].
AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction[1].
AMY-101 (Cp40, 1 mg/kg, sc, injection every 12 h, daily, 7 or 14 days) attenuates fibrosis and infiltration of inflammatory cells in UUO-induced renal fibrosis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight)[1].
Dosage: 0.1 mg/site; 50 μL of 2 mg/mL solution.
Administration: Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.)
Result: Does not cause irritation in healthy gingiva.
Animal Model: UUO and sham-operated mice[3].
Dosage: 1 mg/kg.
Administration: Subcutaneous injection every 12 h, daily, 7 or 14 days.
Result: 1 mg/kg Cp40 had much less severe interstitial fibrosis than control peptide-injected mice.
Clinical Trial
分子量

1789.09 (free base)

Formula

C83H117N23O18S2.xC2HF3O2
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

YICV-{Trp(Me)}-QDW-{Sar}-AHRC-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 50 mg/mL

DMSO 中的溶解度 : ≥ 50 mg/mL

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.89%

COA (296 KB) RP-HPLC (110 KB) MS (199 KB) 元素分析报告 (219 KB)

产品使用指南 (1538 KB)
参考文献

AMY-101 TFA 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMY-1011789738-04-0Cp40AMY101AMY 101Cp 40Cp-40Complement SystemSARS-CoVSARS coronavirusperiodontitisinflammatoryInhibitorinhibitorinhibit

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