2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. Androgen receptor antagonist 12

Androgen receptor antagonist 12 

目录号: HY-169349
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摩尔计算器

Androgen receptor antagonist 12 (Compound EF2) 是一种口服活性雄激素受体 (AR) 拮抗剂 (IC50: 0.30 μM)。Androgen receptor antagonist 12 抑制变体 AR 突变体的转录活性和 AR 阳性 PCa 细胞系的增殖。Androgen receptor antagonist 12 阻断 AR 核易位。Androgen receptor antagonist 12 抑制 C4-2B 异种移植小鼠模型中的肿瘤生长。Androgen receptor antagonist 12 可用于前列腺癌 (PCa) 研究。

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Androgen receptor antagonist 12 Chemical Structure

Androgen receptor antagonist 12 Chemical Structure

CAS No. : 6605-17-0

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Androgen receptor antagonist 12 相关抗体

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生物活性

Androgen receptor antagonist 12 (Compound EF2) is an orally active Androgen receptor (AR) antagonist (IC50: 0.30 μM). Androgen receptor antagonist 12 inhibits transcriptional activity of variant AR mutants and and the proliferation of AR-positive PCa cell lines. Androgen receptor antagonist 12 blocks AR nuclear translocation. Androgen receptor antagonist 12 inhibits tumor growth in a C4-2B xenograft mouse model. Androgen receptor antagonist 12 can be used for prostate cancer (PCa) research[1].

分子量

283.21

Formula

C12H8F3N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Androgen receptor antagonist 12 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Androgen receptor antagonist 126605-17-0Androgen receptor antagonist12Androgen receptor antagonist-12Androgen ReceptorC4-2Bprostate cancerInhibitorinhibitorinhibit

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