2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Androsta-1,4,6-triene-3,17-dione

Androsta-1,4,6-triene-3,17-dione 

目录号: HY-136092
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摩尔计算器

Androsta-1,4,6-triene-3,17-dione 是亲脂性、特异性的芳香酶 (aromatase) 抑制剂，Ki 值为 0.18 μM。Androsta-1,4,6-triene-3,17-dione 可抑制雌激素生物合成，具有避孕作用。Androsta-1,4,6-triene-3,17-dione 能诱导空间记忆障碍。

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Androsta-1,4,6-triene-3,17-dione Chemical Structure

Androsta-1,4,6-triene-3,17-dione Chemical Structure

CAS No. : 633-35-2

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Androsta-1,4,6-triene-3,17-dione 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].

IC50 & Target

Aromatase

 

体内研究
(In Vivo)

Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations[2].
Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (220-250 g)[2]
Dosage: 25 mg/kg, 100 mg/kg
Administration: Subcutaneous injection
Result: Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus.
分子量

282.38

Formula

C19H22O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Androsta-1,4,6-triene-3,17-dione 相关分类

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Keywords:

Androsta-1,4,6-triene-3,17-dione633-35-2Cytochrome P450CYPshippocampusHPestrogensynthetaseantifertilityspatialmemoryimpairmentInhibitorinhibitorinhibit

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