2. Metabolic Enzyme/Protease
  3. PAI-1
  4. Anecortave acetate

Anecortave acetate  (Synonyms: Anecortave)

目录号: HY-116868 纯度: 99.81%
COA 产品使用指南 技术支持

Anecortave acetate 是一种有效的眼部血管抑制剂。Anecortave acetate 抑制由许多不同的血管生成因子诱导的新血管形成，也能增加纤溶酶原激活物抑制子 1 (PAI-1) mRNA表达。Anecortave acetate 可用于研究眼部新生血管疾病。

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Anecortave acetate Chemical Structure

Anecortave acetate Chemical Structure

CAS No. : 7753-60-8

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规格 价格 是否有货 数量
5 mg ￥544
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10 mg ￥880
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Customer Review

Anecortave acetate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].

IC50 & Target

PAI-1[2]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C2C12 EC50
2.12 x 10-1 μM
Compound: VBP3
Inhibition of TNFalpha-induced NFkappaB activation in mouse C2C12 cells incubated for 24 hrs prior to TNFalpha induction measured after 24 hrs by luciferase reporter gene assay
Inhibition of TNFalpha-induced NFkappaB activation in mouse C2C12 cells incubated for 24 hrs prior to TNFalpha induction measured after 24 hrs by luciferase reporter gene assay
[PMID: 23498916]
体内研究
(In Vivo)

Anecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)[2]
Dosage: 5 μl of a 10% suspension of Anecortave acetate
Administration: Injected into eyes
Result: significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels.
Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection.
Clinical Trial
分子量

386.48

Formula

C23H30O5
CAS 号
性状

固体

颜色

White to off-white

中文名称

δ-9(11)-氢化可的松醋酸酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

Methanol 中的溶解度 : 1 mg/mL (2.59 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5875 mL 12.9373 mL 25.8746 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Anecortave acetate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.5875 mL 12.9373 mL 25.8746 mL 64.6864 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anecortave7753-60-8δ-9(11)-氢化可的松醋酸酯PAI-1Plasminogen activator inhibitor-1ocularneovascularizationangiogenicneovascular diseasesInhibitorinhibitorinhibit

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