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  3. Ansatrienin B

Ansatrienin B  (Synonyms: Mycotrienin II)

目录号: HY-122306
产品使用指南

Ansatrienin B (Mycotrienin II) 是从链霉菌中分离得到的一种抗生素 (antibiotic)。Ansatrienin B 对真菌和酵母有活性,但对细菌无活性。Ansatrienin B 具有抗肿瘤活性,可作为 ADC 毒素分子。

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Ansatrienin B Chemical Structure

Ansatrienin B Chemical Structure

CAS No. : 82189-04-6

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规格 价格 是否有货 数量
1 mg ¥7470
3 - 4 周
5 mg   询价  
10 mg   询价  

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin[1][2].

体外研究
(In Vitro)

Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.5 μg/ml, 12.5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively[1].
Ansatrienin B inhibits the release of 45calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC50) value of 21 nM[2].
Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50=58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC50 of 300 nM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

638.79

Formula

C36H50N2O8

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ansatrienin B
目录号:
HY-122306
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