2. Apoptosis
  3. Apoptosis
  4. Anti-CSCs agent-1

Anti-CSCs agent-1 是一种有效的抗 CSCs 剂。 Anti-CSCs agent-1 抑制细胞生长和细胞迁移。Anti-CSCs agent-1 诱导细胞凋亡 (Apoptosis)。Anti-CSCs agent-1 抑制 CSCs 的活力。Anti-CSCs agent-1 可增强 CSCs 中 ROS 的产生。Anti-CSCs agent-1 具有抗肿瘤活性。

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Anti-CSCs agent-1 Chemical Structure

Anti-CSCs agent-1 Chemical Structure

CAS No. : 2251753-58-7

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Anti-CSCs agent-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-CSCs agent-1 is a potent anti-CSCs agent. Anti-CSCs agent-1 inhibits cell growth and cell migration. Anti-CSCs agent-1 induces Apoptosis. Anti-CSCs agent-1 inhibits the viability of CSCs. Anti-CSCs agent-1 enhances the production of ROS in CSCs. Anti-CSCs agent-1 shows antitumor activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
0.7401 μM
Compound: 48
Cytotoxicity activity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
A-375 IC50
0.8929 μM
Compound: 48
Cytotoxicity activity against human A375 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human A375 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
A-375 IC50
3.04 μM
Compound: 48
Cytotoxicity against human A375 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
Cytotoxicity against human A375 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
[PMID: 30433783]
A549 IC50
11.56 μM
Compound: 48
Cytotoxicity activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
B16-F10 IC50
0.6744 μM
Compound: 48
Cytotoxicity activity against mouse B16F10 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse B16F10 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
B16-F10 IC50
1.24 μM
Compound: 48
Cytotoxicity against mouse B16F10 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
Cytotoxicity against mouse B16F10 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
[PMID: 30433783]
Lewis lung carcinoma cell line IC50
0.9066 μM
Compound: 48
Cytotoxicity activity against mouse LLC cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse LLC cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
MDA-MB-231 IC50
3.152 μM
Compound: 48
Cytotoxicity activity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
PANC-1 IC50
1.107 μM
Compound: 48
Cytotoxicity activity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
体外研究
(In Vitro)

Anti-CSCs agent-1 (compound 48) (0, 0.25, 0.5 µM) 以剂量依赖性方式抑制 A375 和 B16F10 细胞的集落形成和细胞迁移[1]。
Anti-CSCs agent-1 (0, 1, 2, 3, 4 µM; 48 h) 诱导细胞凋亡，并以剂量依赖的方式增加 cleaved PARP、cleaved caspase-3、P-53 和 Bax 的表达[1].
Anti-CSCs agent-1 (0, 0.25, 0.5, 1.0, 2.0 µM; 24 h) 以剂量依赖的方式显着上调 E-cadherin 的表达来逆转上皮间质转化[1].
Anti-CSCs agent-1 (0-10 µM; 15 days) 抑制 CSCs 的活力，对球状体 A357、B16F10 细胞的 IC50 值分别为 3.04、1.24 µM[1].
Anti-CSCs agent-1 (0-2 µM; 24 h) 以剂量依赖的方式显着增加 CSCs 中的 ROS 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-CSCs agent-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, 4T1, A375, B16F10, PANC-1, A549, LLC cells
Concentration: 0-50 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 3.152, 0.7401, 0.8929, 0.6744, 1.107, 11.56, 0.9066 µM for MDA-MB-231, 4T1, A375, B16F10, PANC-1, A549, LLC cells, respectively.

Apoptosis Analysis[1]

Cell Line: A375, B16F10 cells
Concentration: 0, 1, 2, 3 µM
Incubation Time: 48 h
Result: Induced cell apoptosis in a dose-dependen manner.

Western Blot Analysis[1]

Cell Line: A375, B16F10 cells
Concentration: 0, 1, 2, 3, 4 µM
Incubation Time: 48 h
Result: Increased the expression of cleaved PARP, cleaved casepase-3, P-53 and Bax in a dose-dependent manner.
体内研究
(In Vivo)

Anti-CSCs agent-1 (5 mg/kg; i.p.; daily for 15 days) 在小鼠体内显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (A375 cells)[1]
Dosage: 5 mg/kg
Administration: I.p.; daily for 15 days
Result: Significantly inhibited tumor growth.
分子量

713.96

Formula

C44H60FN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-CSCs agent-1 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-CSCs agent-12251753-58-7ApoptosismigrationROSantitumorEMTA375B16F10 cellsantiproliferativeapoptosisInhibitorinhibitorinhibit

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