2. Immunology/Inflammation Apoptosis
  3. TNF Receptor Interleukin Related
  4. Anti-inflammatory agent 17

Anti-inflammatory agent 17 是一种有效的具有口服活性的消炎药。Anti-inflammatory agent 17 在体外实验中抑制 IL-6 和 TNF-α 的释放且无细胞毒性。Anti-inflammatory agent 17 在体内显示出抗炎活性。Anti-inflammatory agent 17 具有研究急性肺损伤 (ALI) 的潜力。

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Anti-inflammatory agent 17 Chemical Structure

Anti-inflammatory agent 17 Chemical Structure

CAS No. : 2763226-84-0

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Anti-inflammatory agent 17 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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生物活性

Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI)[1].

IC50 & Target

IL-6

8.254 μM (IC50)

体外研究
(In Vitro)

Anti-inflammatory agent 17 (compound 5b) (10 µM; 24 h) displays no toxicity in J774a.1 cells[1].
Anti-inflammatory agent 17 (1.25, 2.5, 5, 10 µM; 2 h) inhibits the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 17 相关抗体:

Cell Viability Assay[1]

Cell Line: J774a.1 cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Displayed no toxicity in J774a.1 cells.

Immunofluorescence[1]

Cell Line: J774A.1 cells
Concentration: 1.25, 2.5, 5, 10 µM
Incubation Time: 2 h
Result: Inhibited the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner.
体内研究
(In Vivo)

Anti-inflammatory agent 17 (20 mg/kg; intragastric administration) exhibits protective effect on LPS (lipopolysaccharide)-induced ALI in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 mice[1]
Dosage: 20 mg/kg
Administration: Intragastric administration
Result: Exhibited protective effect on LPS-induced ALI in mice.
分子量

357.40

Formula

C20H23NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 17 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 172763226-84-0TNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILanti-inflammatoryAcute lung injury (ALI)lipopolysaccharideJ774a.1 cellsTNF-αIL-6cytotoxicityInhibitorinhibitorinhibit

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