2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. NO Synthase NF-κB Reactive Oxygen Species
  4. Anti-inflammatory agent 21

Anti-inflammatory agent 21 (compound 9o) 是一种具有口服活性且低细胞毒性的抗炎剂，对 NO 的 IC50 为 0.76 μM。Anti-inflammatory agent 21 通过积累 ROS、阻断 NF-κB/MAPK 信号通路来发挥抗炎作用。 Anti-inflammatory agent 21 对关节炎大鼠模型的软骨破坏和炎症细胞浸润有一定的改善作用。

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Anti-inflammatory agent 21 Chemical Structure

Anti-inflammatory agent 21 Chemical Structure

CAS No. : 2408836-40-6

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Anti-inflammatory agent 21 相关抗体

Top Publications Citing Use of Products

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model[1].

IC50 & Target

IC50: 0.76 μM (NO)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
> 40 μM
Compound: 9o
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in presence of LPS by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in presence of LPS by MTT assay
[PMID: 32823004]
RAW264.7 IC50
> 40 μM
Compound: 9o
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
[PMID: 32823004]
RAW264.7 IC50
0.76 μM
Compound: 9o
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
[PMID: 32823004]
分子量

424.42

Formula

C24H21FO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 21 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 212408836-40-6NO SynthaseNF-κBReactive Oxygen SpeciesNitric oxide synthasesNOSNuclear factor-κBNuclear factor-kappaBAnti-inflammatoryOrally activeArthritiscartilageInflammatory cell infiltrationSD ratInhibitorinhibitorinhibit

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产品名称：
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目录号：
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