2. MAPK/ERK Pathway
  3. p38 MAPK
  4. Anti-inflammatory agent 33

Anti-inflammatory agent 33 是一种有效的 p38α 抑制剂。Anti-inflammatory agent 33 抑制 NO 的产生。Anti-inflammatory agent 33 抑制 LPS 诱导的 iNOS、COX-2、p-p38α、p-MK2 蛋白表达。Anti-inflammatory agent 33 具有抗炎活性。

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Anti-inflammatory agent 33 Chemical Structure

Anti-inflammatory agent 33 Chemical Structure

CAS No. : 2816993-09-4

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Anti-inflammatory agent 33 相关抗体

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查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-inflammatory agent 33 is a potent p38α inhibitor. Anti-inflammatory agent 33 inhibits NO production. Anti-inflammatory agent 33 inhibits LPS-induced iNOS, COX-2, p-p38α, p-MK2 protein expression. Anti-inflammatory agent 33 shows anti-inflammatory activity[1].

体外研究
(In Vitro)

Anti-inflammatory agent 33 (compound 8j) (10, 5, 2.5, 1.25, 0.675 μM; 1+24 h) 在 LPS 诱导的 RAW264.7 细胞中显着抑制 NO 的产生，抑制率为93.97%，IC50 值为 1.25 µM[1]。
Anti-inflammatory agent 33 (1.25, 2.5, 5, 10, 20 µM; 1+24 h) 抑制 TNF-α 和 IL-1β 的产生，IC50 值分别为 11.5, 8.48 μM[1]。
Anti-inflammatory agent 33 (1, 3, 5 µM; 1+24 h) 在 RAW264.7 细胞中呈剂量依赖性抑制 LPS 诱导的 iNOS、COX-2、p-p38α、p-MK2 蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 33 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 1, 3, 5 µM
Incubation Time: 1+24 h
Result: Inhibited the LPS-induced expression of pro-inflammatory mediators iNOS, COX-2, p-p38α; p-MK2 in the RAW264.7 cells.
体内研究
(In Vivo)

Anti-inflammatory agent 33 (10, 30 mg/kg; once a day for 14 days) 在大鼠体内表现出剂量依赖性的抗炎活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 160-180 g, female Sprague–Dawley rats (AIA model)[1]
Dosage: 10, 30 mg/kg
Administration: Once a day for 14 days
Result: Significantly reduced the swelling of the feet of the rats in a dose-dependent manner.
分子量

433.44

Formula

C22H15N3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 33 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 332816993-09-4p38 MAPKAnti-InflammatoryNOLPSRAW264.7 cellsiNOSCOX-2p-p38αp-MK2Inhibitorinhibitorinhibit

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产品名称：
Anti-inflammatory agent 33
目录号：
HY-151921
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