2. Anti-infection
  3. Bacterial
  4. Anti-MRSA agent 20

Anti-MRSA agent 20 (Compound a4) 是一种针对 MRSA 的抗菌剂 (MIC: < 0.03125 μg/mL)。Anti-MRSA agent 20 与核糖体肽基转移酶中心结合，通过抑制 MRSA 毒素合成和细菌分裂来抑制细菌生存。Anti-MRSA agent 20 显著减少 MRSA 感染小鼠的肺部 MRSA 负荷并减轻肺损伤 (ED50 = 6.48 mg/kg)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Anti-MRSA agent 20 Chemical Structure

Anti-MRSA agent 20 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Anti-MRSA agent 20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-MRSA agent 20 (Compound a4) is an anti-microbial agent (MIC: < 0.03125 μg/mL) against MRSA). Anti-MRSA agent 20 binds to the ribosomal peptidyl transferase center and inhibits bacterial survival by inhibiting MRSA toxin synthesis and bacterial division. Anti-MRSA agent 20 significantly reduces the MRSA load in the lungs and attenuates lung injury in the MRSA-infected mice (ED50 = 6.48 mg/kg)[1].

体外研究
(In Vitro)

Anti-MRSA agent 20 抑制 Staphylococcus aureus ATCC 29213、MRSA ATCC 43300 和 MRSE ATCC 51625 生长，其最小抑菌浓度 (MIC) 低于 0.03125 μg/mL[1]。
Anti-MRSA agent 20 (1 × MIC-6 × MIC, 0-24 h) 在时间-致死动力学实验中对 MRSA 具有抑制活性[1]。
Anti-MRSA 20 (21 天) 可减缓细菌耐药性的产生，在第 17-18 天达到 8 μg/mL 的 MIC 值[1]。
Anti-MRSA agent 20 (LC50 为 165.0 μg/mL) 仅在高浓度范围 (> 120 μg/mL) 对 HEK293 和 HEPG2 细胞有毒性，在低浓度范围 (0.5-1 μg/mL) 抑制 MRSA 毒素的合成，对斑马鱼胚胎无明显致畸作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-MRSA agent 20 相关抗体:

Cell Viability Assay[1]

Cell Line: MRSA
Concentration: 1 × MIC, 3 × MIC, 6 × MIC
Incubation Time: 24 h
Result: Killed 99.9 % of MRSA at 3 × MIC after 4 h.
Killed 99.99 % of MRSA at 6 × MIC after 12 h.

Cell Viability Assay[1]

Cell Line: HEK293 and HEPG2 cells
Concentration: 7.5, 15, 30, 60, 120, 250 μg/mL
Incubation Time: 6 h
Result: Showed minor toxicity to HEK293 cells at concentrations up to 120 μg/mL.
Displayed toxicity to HEPG2 cells at a concentration of 250 µg/mL.
体内研究
(In Vivo)

Anti-MRSA agent 20 (2.5-40 mg/kg, 腹腔注射, 细菌感染后 1 h) 减少 MRSA 感染小鼠肺部细菌负荷，减轻肺部病变，增加其存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRSA-infected mice[1]
Dosage: 2.5, 5, 10, 20, 40 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Increased survival of mice.
Reduced bacterial load in lungs of mice.
Alleviated MRSA-induced lung lesions such as congestion, hemorrhage and inflammatory cell infiltration.
分子量

661.87

Formula

C34H47NO8S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-MRSA agent 20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-MRSA agent 20BacterialAntibacterialMRSAToxicityIntrapulmonary infectionsHEPG2 cellsHEK293 cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Anti-MRSA agent 20
目录号：
HY-168705
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z