Anti-neuroinflammation agent 1 

Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype^[1].

Anti-neuroinflammation agent 1 (BMP 29) 在体外显示出更有效的抗神经炎症活性，并且对 BV2 小胶质细胞没有毒性。 在脂多糖（LPS）诱导的 BV2 小胶质细胞中，Anti-neuroinflammation agent 1 显着减少M1表型小胶质细胞的数量，但显着增加M2表型小胶质细胞的数量。Anti-neuroinflammation agent 1 显着减少炎症细胞因子（IL-18、IL-1β、TNF-α）的分泌，但增加 LPS 诱导的 BV2 小胶质细胞分泌抗炎细胞因子（IL-10）。此外，Anti-neuroinflammation agent 1 还可抑制 NOD 样受体 NLRP3 炎症小体的形成，并下调 LPS 诱导的 BV2 小胶质细胞中丙酮酸激酶 M2 亚型的表达^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

在小鼠中，Anti-neuroinflammation agent 1 (BMP 29) 通过降低诱导型一氧化氮合酶的表达来减轻铜宗诱导的炎症和脱髓鞘小鼠的神经炎症，但会增加 CD206 的表达^[1] 。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

523.86

C₂₂H₂₀ClF₆N₃O₃

2968412-77-1

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• [1]. Yang Yang, et al. Discovery of anti-neuroinflammatory agents from 1,4,5,6-tetrahydrobenzo[2,3]oxepino[4,5-d]pyrimidin-2-amine derivatives by regulating microglia polarization. Eur J Med Chem. 2023 Jul 27;259:115688.  [Content Brief]