2. MAPK/ERK Pathway NF-κB
  3. p38 MAPK NF-κB RANKL/RANK
  4. Anti-osteoporosis agent-11

Anti-osteoporosis agent-11 (compound 3k) 是一种靶向破骨细胞的抗骨质疏松化合物。Anti-osteoporosis agent-11 对破骨细胞分化的抑制作用最为显著，IC50 值为 0.36 μM。此外，Anti-osteoporosis agent-11 通过阻断 rankl 诱导的丝裂原活化蛋白激酶 (MAPK) 和 NF-κB 信号通路，来抑制破骨细胞形成、骨吸收和破骨细胞特异性基因的表达。

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Anti-osteoporosis agent-11 Chemical Structure

Anti-osteoporosis agent-11 Chemical Structure

CAS No. : 2869099-50-1

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Anti-osteoporosis agent-11 相关抗体

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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  • 生物活性

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  • 参考文献

生物活性

Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways[1].

分子量

497.31

Formula

C23H17NO2Se2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-osteoporosis agent-11 相关分类

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Keywords:

Anti-osteoporosis agent-112869099-50-1p38 MAPKNF-κBRANKL/RANKNuclear factor-κBNuclear factor-kappaBosteoclastsosteoporosisMAPKbone resorptioncell differentiationInhibitorinhibitorinhibit

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