Antibacterial agent 140 chloride 

Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen photosensitizer for simultaneous dual applications of Gram-positive bacteria (G+) detection and treatment. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+) from other bacteria due to its interaction with lipoteichoic acids (LTA). Antibacterial agent 140 chloride  also possessed robust antibacterial activity for G+ under light irradiation^[1].

Antibacterial agent 140 chloride (0.1-5 μg/mL, 1 h) 在黑暗中表现出 78%-0% 的剂量依赖性，表明 Ru2 对 S. aureus 具有暗毒性^[1]。
Antibacterial agent 140 chloride（0.1-5 μg/mL；1 h) 在 120s 光照射下表现出明显的剂量依赖性和时间依赖性，Ru2 在极低浓度光照射下几乎完全抑制金黄色葡萄球菌的生长^[1]。
Antibacterial agent 140 chloride（0.1-5 μg/mL；1 h) 与 HeLa 细胞孵育后，80% 以上的 HeLa 细胞存活, 在 ≤32 μM 的光照下，>73% 的 HeLa 细胞存活^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 140 chloride（20 μg/mL/50 μL; 1-10 days) 使得金黄色葡萄球菌感染导致的伤口大小明显减小，雌性昆明小鼠伤口在 7 天后几乎完全愈合。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1162.10

C₆₁H₄₄Cl₂N₈Ru₂^-

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mengling Liu, et al. Specific discrimination and efficient elimination of gram-positive bacteria by an aggregation-induced emission-active ruthenium (II) photosensitizer. Eur J Med Chem. 2023 May 5;251:115249.  [Content Brief]