Antibacterial agent 166 

Antibacterial agent 166 (Compound 19q), a derivative of Nitisinone (HY-B0607), is a selective and orally active Fusobacterium nucleatum inhibitor with a MIC₅₀ of 1 μg/mL. Antibacterial agent 166 effectively attenuates the migratory ability of MC-38 cells induced by Fusobacterium nucleatum. Antibacterial agent 166 is a promising anti-F. nucleatum lead compound and can be used for colorectal cancer (CRC) research^[1].

Antibacterial agent 166 (Compound 19q) (1-4μg/mL, 0-72 h) 能以剂量依赖的方式抑制 Fusobacterium nucleatum 的生长和生物膜的形成^[1]。
Antibacterial agent 166 (1-4 μg/mL, 4-48 h) 通过下调 NTR 的表达来抑制 Fusobacterium nucleatum 的生长^[1]。
Antibacterial agent 166 (1-4 μg/mL, 48 h) 在对数后期以剂量依赖的方式下调 tnaA 基因的表达^[1]。
Antibacterial agent 166 (2-4 μg/mL, 48 h) 在 Fusobacterium nucleatum 的刺激下，对 MC-38 细胞具有更强的迁移抑制能力^[1]。
Antibacterial agent 166对 MC-38 细胞表现出有效的抑制活性，IC₅₀ 为11 μM^[1]。
Antibacterial agent 166对两种人类正常细胞系具有中度至弱的抗增殖活性，IC₅₀ 为16 μM，具有较低的细胞毒性^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 166 (Compound 19q) (1500 mg/kg, 单次给药) 对器官的毒副作用很小^[1]。
Antibacterial agent 166 (20 mg/kg, 口服, 单次给药) 能在肠道局部抑制 Fusobacterium nucleatum，且具有较低的全身毒性^[1]。
Antibacterial agent 166 (1 mg/kg, 静脉注射) 半衰期约为0.068 h, 峰值浓度C_max和血浆清除率(CL) 分别为85 ng/mL和36054 mL/h/mg^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

281.65

C₁₁H₈ClN₃O₄

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pan Z, et al. Discovery of New Fusobacterium nucleatum Inhibitors to Attenuate Migratory Capability of Colon Cancer Cells by the Drug Repositioning Strategy. Journal of Medicinal Chemistry. 2023 Nov 20.