2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Bacterial Lactate Dehydrogenase Reactive Oxygen Species
  4. Antibiofilm agent-5

Antibiofilm agent-5 (compound 6c) 是一种具有有效抗生物膜活性的多靶点抗菌(antibacterial) 剂。Antibiofilm agent-5 可通过灭活乳酸脱氢酶 (lactate dehydrogenase) 来诱导代谢功能障碍，促进活性氧 (reactive oxygen species) 的积累，从而减少还原型谷胱甘肽，最终导致细菌氧化损伤。Antibiofilm agent-5 可用于难治性生物膜强化细菌感染的研究。

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Antibiofilm agent-5 Chemical Structure

Antibiofilm agent-5 Chemical Structure

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Antibiofilm agent-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibiofilm agent-5 (compound 6c) is a multitargeting antibacterial agent with potent antibiofilm activity. Antibiofilm agent-5 could induce metabolic dysfunction by deactivating lactate dehydrogenase and promote the accumulation of reactive oxygen species to decrease the reduced glutathione and ultimately cause oxidative damage in bacteria. Antibiofilm agent-5 can be used for the research of refractory biofilm-intensified bacterial infections[1].

体外研究
(In Vitro)

Antibiofilm agent-5 (compound 6c) 对鲍曼不动杆菌和大肠杆菌具有比norfloxacin (HY-B0132)更好的抑制活性，其MIC值均为0.0066 mmol/L[1]。
Antibiofilm agent-5 可以插入DNA中形成6c-DNA超分子复合物并引发细胞死亡[1]。
Antibiofilm agent-5对人红细胞有不明显的溶血作用，对人正常肝细胞(LO2)和肺上皮细胞(BEAS-2B)具有低细胞毒性，且无穿过血脑屏障的风险[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibiofilm agent-5 相关抗体:
分子量

608.11

Formula

C25H34ClN9O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibiofilm agent-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibiofilm agent-5Antibiofilm agent5Antibiofilm agent 5BacterialLactate DehydrogenaseReactive Oxygen SpeciesLDHAcinetobacter baumanniiEscherichia coliantibiofilmantibacterialmetabolic dysfunctionInhibitorinhibitorinhibit

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