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  4. Ikaros 抗体 (YA988)

Ikaros 抗体 (YA988)

目录号: HY-P81282A
抗体使用指南 技术支持

Ikaros Antibody (YA988) 是无偶联基团的、靶向 Ikaros 的 IgG 抗体 (克隆号:YA988)。Ikaros Antibody (YA988) 可用于人背景下的 IHC-P 实验。

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规格 价格 是否有货
10 μL ¥470 询问价格 & 货期
50 μL ¥1220 询问价格 & 货期
100 μL ¥2000 询问价格 & 货期

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Compound Screening Library
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描述

Ikaros Antibody (YA988) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA988), targeting Ikaros. Ikaros Antibody (YA988) can be used for IHC-P experiment in human background.

研究背景

The related gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of The protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for The related gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target related genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

基因 ID

10320

同用名
CLL associated antigen KW 6; DNA-binding protein Ikaros; hIk 1; hIk-1; Hs.54452; IK1; Ikaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; Ikzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (Ikaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.
纯度

Affinity Purified

偶联

Non-conjugated

修饰

Unmodified

研究领域

Epigenetics and Nuclear Signaling

产品类别

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

克隆性

Recombinant, Monoclonal

宿主

Rabbit

反应物种

Human

蛋白数据库

Q13422

推荐稀释比例

IHC: 1/100-1/200

应用

IHC-P

性状

液体

组分

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.180.

保存条件 & 期限

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

运输条件

Shipping with blue ice.

同型

IgG

敏感性

Endogenous

免疫原

A synthesized peptide derived from human Ikaros

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ikaros Antibody (YA988)
目录号:
HY-P81282A
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