SKP2 抗体 (YA1332)

SKP2 Antibody (YA1332) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1332), targeting SKP2, with a predicted molecular weight of 48 kDa (observed band size: 48 kDa). SKP2 Antibody (YA1332) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

The related gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by The related gene belongs to the Fbls class; in addition to an F-box, The protein contains 10 tandem leucine-rich repeats. The protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, The related gene is established as a protooncorelated gene causally involved in the pathorelated genesis of lymphomas. Alternative splicing of The related gene related generates three transcript variants encoding different isoforms.

6502

Predicted band size: 48 kDa; Observed band size: 48 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Cell Biology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

Q13309

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;FC: 1/50-1/100

WB, IHC-P, ICC/IF, FC

液体

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human SKP2