2. Apoptosis Autophagy Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Ferroptosis Autophagy Reactive Oxygen Species
  4. Anticancer agent 194

Anticancer agent 194 (compound 10p) 是一种铁死亡 (ferroptosis) 和自噬 (autophagy) 诱导剂。Anticancer agent 194 将结肠癌细胞周期阻滞在 G2/M 期，但不能诱导细胞凋亡。Anticancer agent 194 通过 ROS 的大量积累独立触发细胞铁死亡和自噬。

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Anticancer agent 194 Chemical Structure

Anticancer agent 194 Chemical Structure

CAS No. : 2767204-90-8

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Anticancer agent 194 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 194 (compound 10p) is a ferroptosis and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS[1].

体外研究
(In Vitro)

Anticancer agent 194（化合物 10p；1-10 μM；48 小时）对 HT-29 癌细胞具有抗增殖活性，IC50 为 1.97 μM[1]。
Anticancer agent 194（化合物 10p；1-4 μM；48 小时）以浓度依赖性方式将细胞周期阻滞在 G2/M 期[1]。
Anticancer agent 194（化合物 10p；0.5-4 μM；48 小时）以浓度依赖性方式降低 GPX4 的表达[1]。
Anticancer agent 194（化合物 10p；1-4 μM；48 小时）诱导 HT-29 细胞自噬[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 194 相关抗体:

Cell Viability Assay[1]

Cell Line: HT-29 cells
Concentration: 1 μM, 5 μM and 10 μM
Incubation Time: 48 h
Result: Induced cell death.

Cell Cycle Analysis[1]

Cell Line: HT-29 cells
Concentration: 1 μM, 2 μM and 4 μM
Incubation Time: 48 h
Result: Arrested cell cycle at G2/M phase.

Western Blot Analysis[1]

Cell Line: HT-29 cells
Concentration: 0.5 μM, 1 μM, 2 μM and 4 μM
Incubation Time: 48 h
Result: Decreased the expression of GPX4 in a concentration-dependent manner.

Cell Autophagy Assay[1]

Cell Line: HT-29 cells
Concentration: 1 μM, 2 μM and 4 μM
Incubation Time: 48 h
Result: Induced autophagy of HT-29 cells.
分子量

269.73

Formula

C12H16ClN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 194 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Anticancer agent 1942767204-90-8Anticancer agent194Anticancer agent-194FerroptosisAutophagyReactive Oxygen Speciesferroptosis inducerautophagycell cycle at G2/M phaseROSInhibitorinhibitorinhibit

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目录号：
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