2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Caspase PARP Bcl-2 Family
  4. Anticancer agent 201

Anticancer agent 201 (Compound 2f) 对多种肿瘤细胞系的 IC50 值在低微摩尔范围内。Anticancer agent 201 对 CCRF-CEM 细胞具有高体外细胞毒性，通过激活线粒体内在途径中的 caspase-3 并裂解 PARP ，以及降低 Bcl-2 和 Bcl-XL 蛋白的表达，从而诱导细胞凋亡 (apotosis)。Anticancer agent 201 可用于癌症研究。

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Anticancer agent 201 Chemical Structure

Anticancer agent 201 Chemical Structure

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Anticancer agent 201 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 201 (Compound 2f) has IC50 values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of Bcl-2 and Bcl-XL proteins. Anticancer agent 201 can be used in cancer research[1].

IC50 & Target

Caspase-3

 

Bcl-2

 

Bcl-xL

 

体外研究
(In Vitro)

Anticancer agent 201 (Compound 2f) (3.5 μM, 17.5 μM; 24 小时) 能显著地诱导细胞毒性反应、增加凋亡细胞的数量，并导致 CCRF-CEM 细胞的线粒体膜电位呈剂量依赖性降低[1]。
Anticancer agent 201 (3.5 μM, 17.5 μM; 24 小时) 在 CCRF-CEM 细胞中阻塞或减慢 G0/G1 期的细胞周期，降低 S 期细胞比例，并能抑制 RNA 的合成[1]。

Anticancer agent 201 对 8 种肿瘤 (包括多药耐药变异体) 和 2 种正常成纤维细胞系的细胞毒活性[1]

Cell lines CCRF-CEM CEM-DNR K562 K562-TAX A549 HCT116 HCT116p53-/- U20S BJ MRC-5
IC50 (μM) 3.5 4.9 23 17 11 10 18 19 ＞50 27

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 201 相关抗体:

Apoptosis Analysis[1]

Cell Line: CCRF-CEM cancer cell line
Concentration: 3.5 μM, 17.5 μM
Incubation Time: 24h
Result: Induced the strongest cytotoxic reaction and the number of apoptotic cells increased significantly.
Resulted in a significant decrease in mitochondrial membrane potential of CCRF-CEM cells in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: CCRF-CEM cancer cell line
Concentration: 3.5 μM, 17.5 μM
Incubation Time: 24h
Result: Caused the cell cycle to be blocked or slowed down in the G0/G1 phase, while the proportion of S phase cells decreases.
At 17.5 μM, the mitosis rate of the cells decreased.
At 3.5 μM increased the proportion of BRDU-positive cells.
At 17.5μM, the proportion of BRDU-positive cells decreased.
At 17.5μM, RNA synthesis almost completely stopped.

Western Blot Analysis[1]

Cell Line: CCRF-CEM cancer cell line
Concentration: 3.5 μM, 17.5 μM
Incubation Time: 24h
Result: Leaded to decreased expression of both Bcl-2 and Bcl-XL.
At 17.5μM, caused the activation of caspase-3 and the cleavage of PARP.
分子量

578.75

Formula

C34H49F3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 201 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 201Anticancer agent201Anticancer agent-201ApoptosisCaspasePARPBcl-2 Familypoly ADP ribose polymeraseTriterpenoid PyroneCytotoxicityMitochondriaCCRF-CEMInhibitorinhibitorinhibit

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