2. Apoptosis PI3K/Akt/mTOR
  3. Apoptosis Akt
  4. Anticancer agent 253

Anticancer agent 253 (Compound 26) 对乳腺癌细胞具有抗癌活性，IC50s 为 6 μM (MCF-7)、10 μM (MDA-MB-231)和 6.4 μM (4T1 细胞)。Anticancer agent 253 可阻止细胞周期并诱导癌细胞中线粒体介导的细胞凋亡 (Apoptosi)。Anticancer agent 253 可抑制人类乳腺癌和前列腺癌中的 Akt 磷酸化。

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Anticancer agent 253 Chemical Structure

Anticancer agent 253 Chemical Structure

CAS No. : 1983924-33-9

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Anticancer agent 253 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 253 (Compound 26) has anti-cancer activity against breast cancer cells, with IC50s of 6 μM (MCF-7), 10 μM (MDA-MB-231) and 6.4 μM (4T1 cells). Anticancer agent 253 arrests cell cycle and induces mitochondria-mediated apoptosis in cancer cells. Anticancer agent 253 inhibits Akt phosphorylation in human breast and prostate cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
6.4 μM
Compound: 26
Cytotoxicity against mouse 4T1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
DU-145 IC50
8.7 μM
Compound: 26
Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
HEK293 IC50
46 μM
Compound: 26
Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
MCF7 IC50
6 μM
Compound: 26
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
MDA-MB-231 IC50
10 μM
Compound: 26
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
PC-3 IC50
19.4 μM
Compound: 26
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27496212]
分子量

500.51

Formula

C29H23F3N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 253 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 2531983924-33-9Anticancer agent253Anticancer agent-253ApoptosisAktPKBProtein kinase Bprostate cancerbreast cancerInhibitorinhibitorinhibit

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