2. Apoptosis
  3. Apoptosis Caspase Bcl-2 Family
  4. Anticancer agent 63

Anticancer agent 63 (化合物 3h) 对SW480、HeLa、A549和MCF-7等不同癌细胞株的活性均有明显的降低作用，在24 h 时其 IC50 值分别为 4.9、11.5、9.4和3.4 μM。Anticancer agent 63 通过下调 Bcl-2 表达、上调 IL-2 和 Caspase-3 表达诱导 MCF-7 细胞凋亡。Anticancer agent 63 还具有抗氧化活性。

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Anticancer agent 63 Chemical Structure

Anticancer agent 63 Chemical Structure

CAS No. : 2529657-32-5

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Anticancer agent 63 相关抗体

Top Publications Citing Use of Products

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 63 (compound 3h) shows active in reducing the viability of different cancer cell lines, including SW480, HeLa, A549 and MCF-7, with IC50 values at 24 h of 4.9, 11.5, 9.4, and 3.4 μM, respectively. Anticancer agent 63 induce apoptosis in MCF-7 cells via down-regulating the expression of Bcl-2 and up-regulating the expression of IL-2 and Caspase-3. Anticancer agent 63 also shows antioxidant activity[1].

IC50 & Target

Caspase-3

 

Bcl-2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
15.2 μM
Compound: 3h
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32987314]
A549 IC50
18.5 μM
Compound: 3h
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32987314]
A549 IC50
9.4 μM
Compound: 3h
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 32987314]
HeLa IC50
11.5 μM
Compound: 3h
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 32987314]
HeLa IC50
17.4 μM
Compound: 3h
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32987314]
HeLa IC50
19.7 μM
Compound: 3h
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32987314]
MCF7 IC50
2.8 μM
Compound: 3h
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32987314]
MCF7 IC50
3.4 μM
Compound: 3h
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 32987314]
MCF7 IC50
4.3 μM
Compound: 3h
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32987314]
SW480 IC50
3.3 μM
Compound: 3h
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32987314]
SW480 IC50
4.2 μM
Compound: 3h
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32987314]
SW480 IC50
4.9 μM
Compound: 3h
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 32987314]
分子量

394.33

Formula

C17H24F3NOSe
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 63 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 632529657-32-5Anticancer agent63Anticancer agent-63ApoptosisCaspaseBcl-2 FamilySW480HeLaA549MCF-7NSAIDs-SeCF3 derivativeNSAIDsSelenocyanatesTrifluoromethyl selenidesanticancerprostateoral carcinomaInhibitorinhibitorinhibit

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