2. Cell Cycle/DNA Damage Apoptosis Protein Tyrosine Kinase/RTK
  3. Topoisomerase c-Myc Apoptosis ROS Kinase
  4. Anticancer agent 76

Anticancer agent 76 (Compound CT2-3) 是一种抗癌剂。Anticancer agent 76 能显著抑制人 NSCLC 细胞增殖，诱导细胞周期阻滞、ROS 生成和细胞凋亡（apoptosis）。

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Anticancer agent 76 Chemical Structure

Anticancer agent 76 Chemical Structure

CAS No. : 2448091-11-8

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Anticancer agent 76 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
41.63 μM
Compound: CT2-3
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32044229]
NCI-H460 IC50
38.03 μM
Compound: CT2-3
Antiproliferative activity against human H460 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human H460 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32044229]
体外研究
(In Vitro)

Anticancer agent 76 (Compound CT2-3) (0-80 μM, 24 h) inhibits the proliferation of human NSCLC cells[1].
Anticancer agent 76 (40 μM, 24 h) arrests cell cycle at G1 phase, induces apoptosis and ROS, suppresses the expression of c-Myc and topoisomerases in NSCLC cells [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 76 相关抗体:

Cell Proliferation Assay[1]

Cell Line: A549 and H460
Concentration: 0, 10, 20, 40, 60 and 80 μM
Incubation Time: 24 h
Result: Inhibited the proliferation with IC50 values of 41.63 μM and 38.03 μM against A549 and H460 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: H460
Concentration: 40 μM
Incubation Time: 24 h
Result: Resulted in increasing cell populations at the G1 phase, down-regulated CDK4, CDK6 and cyclin D1.

Apoptosis Analysis[1]

Cell Line: A549 and H460
Concentration: 20 μM and 40 μM
Incubation Time: 24 h
Result: Induced apoptosis.

Western Blot Analysis[1]

Cell Line: H460 cell
Concentration: 40 μM
Incubation Time: 24 h
Result: Down-regulated mRNA of TOP2B, TOP3B and c-Myc.
分子量

543.67

Formula

C32H33NO5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 76 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 762448091-11-8Anticancer agent76Anticancer agent-76Topoisomerasec-MycApoptosisROS KinaseMycNSCLCnon-small cell lung cancertopoisomerasesA549H460Inhibitorinhibitorinhibit

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