2. Anti-infection
  3. Parasite
  4. Antiparasitic agent-25

Antiparasitic agent-25 (Compounds 11) 是一种有口服活性的抗寄生虫剂。Antiparasitic agent-25 可抑制寄生虫的入侵和复制能力，对弓形虫有不可逆作用，可显著降低弓形虫的复制率，IC50 值为 6.33 μM，并表现出低细胞毒性，CC50 值为 285 μM。

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Antiparasitic agent-25 Chemical Structure

Antiparasitic agent-25 Chemical Structure

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Antiparasitic agent-25 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiparasitic agent-25 (Compounds 11) is an orally active antiparasitic agent. Antiparasitic agent-25 inhibits both parasite invasion and replication ability and has irreversible action against Toxoplasma gondii, significantly reducing the replication rate of Toxoplasma gondii with an IC50 value of 6.33 μM, and demonstrates low cytotoxicity with a CC50 value of 285 μM[1].

IC50 & Target

IC50: 6.33 μM (Toxoplasma gondii)[1]
体外研究
(In Vitro)

Antiparasitic agent-25 (10 μM, 24-72 小时) 对弓形虫具有不可逆作用[1]。
Antiparasitic agent-25 (10 μM; 30 分钟) 显著减少入侵弓形虫的数量，表明它能抑制弓形虫入侵宿主细胞[1]。
Antiparasitic agent-25 (10 μM, 24 小时) 将大多数速殖子复制限制在 0-1 个周期，表现出普遍仅能容纳一个或两个速殖子大小的空泡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antiparasitic agent-25 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HFF cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Constrained the replication of the majority of tachyzoites to 0-1 cycles, manifesting a prevalence of vacuoles sized for accommodating only one or two tachyzoites.

Cell Invasion Assay[1]

Cell Line: HFF cells
Concentration: 10 μM
Incubation Time: 30 min
Result: Significantly cut down the number of invaded parasites, indicating could inhibit the invasion of parasites into host cells.
体内研究
(In Vivo)

Antiparasitic agent-25 (50 mg/kg; 口服给药；每天2次，连续5天) 可减少寄生虫数量，统计上显著延长了中位生存期，但不足以完全抑制体内寄生虫的生长，导致持续感染，从而使受感染小鼠有较高的死亡率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Kunming mice (eight-nine weeks old) (Inoculated with 1 × 103 tachyzoites of the RH strain via intraperitoneal (ip) injection.)[1]
Dosage: 50 mg/kg (Dissolved in PBS including 25% PEG-400 and 5% DMSO)
Administration: Oral gavage (p.o.); twice daily for 5 days
Result: Reduced parasite numbers, statistically significantly extended the median survival time, but insufficient to completely suppress the growth of parasites in vivo, leading to continued infection and consequently high mortality rates among infected mice.
分子量

531.60

Formula

C32H29N5O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiparasitic agent-25 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiparasitic agent-25Antiparasitic agent25Antiparasitic agent 25ParasiteHFF cellsantiparasiticToxoplasma gondiiquinazolinonediaryletherorally activeparasiteInhibitorinhibitorinhibit

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