2. Anti-infection
  3. Parasite
  4. Antitrypanosomal agent 4

Antitrypanosomal agent 4 (compound 19) 是一种有效且具有血脑屏障渗透性的抗锥体虫剂，对克氏锥虫 (T. cruzi) 和布氏锥虫 (T. b. brucei) 有良好的抗性，IC50 分别为 1.2 μM 和 70 nM。

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Antitrypanosomal agent 4 Chemical Structure

Antitrypanosomal agent 4 Chemical Structure

CAS No. : 2456427-48-6

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Antitrypanosomal agent 4 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC50s of 1.2 μM and 70 nM, respectively[1]. Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

Trypanosoma

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 CC50
> 125 μM
Compound: 19
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32652409]
THP-1 CC50
> 100 μM
Compound: 19
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32652409]
分子量

419.84

Formula

C18H14ClN3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitrypanosomal agent 4 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitrypanosomal agent 42456427-48-6Antitrypanosomal agent4Antitrypanosomal agent-4ParasiteT.CruziT.b.bruceiAntitrypanosomalBBB permeableInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-146049
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