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  4. Antitrypanosomal agent 9

Antitrypanosomal agent 9 (compound 1) 是一种有效的抗锥虫体剂。Antitrypanosomal agent 9 显示出对 T. b. brucei 的抑制活性，其 IC50 为 1.15 μM。Antitrypanosomal agent 9 可用于人类非洲锥虫病 (HAT) 研究。

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Antitrypanosomal agent 9 Chemical Structure

Antitrypanosomal agent 9 Chemical Structure

CAS No. : 438474-67-0

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Antitrypanosomal agent 9 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].

IC50 & Target

Trypanosoma

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
1.15 μM
Compound: 1
Antitrypanosomal activity against Trypanosoma brucei brucei infected in HEK293 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Antitrypanosomal activity against Trypanosoma brucei brucei infected in HEK293 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
10.1039/C4MD00406J
L6 IC50
107 μM
Compound: 1
Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 96 hrs by beta-galactosidase reporter gene assay
Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 96 hrs by beta-galactosidase reporter gene assay
10.1039/C4MD00406J
L6 IC50
186 μM
Compound: 1
Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
10.1039/C4MD00406J
体外研究
(In Vitro)

Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively[1].
Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitrypanosomal agent 9 相关抗体:
分子量

353.45

Formula

C22H27NO3
CAS 号
性状

粉末

颜色

Light brown to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Antitrypanosomal agent 9 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitrypanosomal agent 9438474-67-0Antitrypanosomal agent9Antitrypanosomal agent-9Parasiterat skeletal myoblastsL6 cellsT. b. rhodesienseT. cruziL. donovaniP. falciparumantitrypanosomalhuman African trypanosomiasisHATInhibitorinhibitorinhibit

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