2. Cell Cycle/DNA Damage Apoptosis
  3. DNA/RNA Synthesis Apoptosis
  4. Antitumor agent-43

Antitumor agent-43 (Compound 4B) 是一种抗肿瘤剂，对 T-24 细胞的IC50值为0.5 µM. Antitumor agent-43 (Compound 4B)诱导细胞周期阻滞在G2/M期。

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Antitumor agent-43 Chemical Structure

Antitumor agent-43 Chemical Structure

CAS No. : 2766035-37-2

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Antitumor agent-43 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-43 (Compound 4B) is a potent antitumor agent, with an IC50of 0.5 µM for (T-24 cell). Antitumor agent-43 (Compound 4B) induces cell cycle arrest at G2/M phase[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
1.3 μM
Compound: 4B
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 35092899]
MGC-803 IC50
1.1 μM
Compound: 4B
Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 35092899]
SK-OV-3 IC50
8.9 μM
Compound: 4B
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 35092899]
T-24 IC50
0.5 μM
Compound: 4B
Antiproliferative activity against human T24 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human T24 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 35092899]
WI-38 IC50
14.8 μM
Compound: 4B
Antiproliferative activity against human WI-38 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
Antiproliferative activity against human WI-38 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
[PMID: 35092899]
体外研究
(In Vitro)

Antitumor agent-43 towards T-24, MGC80-3, SK-OV-3, HepG2 cells with IC50of 0.5, 1.1, 8.9 and 1.3µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-43 相关抗体:
体内研究
(In Vivo)

Antitumor agent-43 effectively inhibits tumor growth (49.5%) in a mouse xenograft model bearing T-24. [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

276.25

Formula

C16H8N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-43 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-432766035-37-2Antitumor agent43Antitumor agent 43DNA/RNA SynthesisApoptosistumorDNA damageantitumormitochondrial；apoptosisInhibitorinhibitorinhibit

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