2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis c-Met/HGFR
  4. Antitumor agent-45

Antitumor agent-45 (Compound 21) 可诱导 A549 细胞凋亡并将细胞阻滞在 G0/G1 和 G2/M期。Antitumor agent-45 (Compound 21) 抑制c-Met 表达。

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Antitumor agent-45 Chemical Structure

Antitumor agent-45 Chemical Structure

CAS No. : 2581082-74-6

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Antitumor agent-45 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-45 (Compound 21) could induce and stimulate A549 cells apoptosis in G0/G1 and G2/M phase. Antitumor agent-45 (Compound 21) inhibits c-Met expression to regulate the growth of tumor cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1.06 μM
Compound: 21
Antiproliferative activity against human A549 cells expressing c-Met after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells expressing c-Met after 48 hrs by MTT assay
[PMID: 35227978]
HeLa IC50
10.87 μM
Compound: 21
Antiproliferative activity against human HeLa cells expressing c-Met after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells expressing c-Met after 48 hrs by MTT assay
[PMID: 35227978]
MCF7 IC50
0.11 μM
Compound: 21
Antiproliferative activity against human MCF7 cells expressing c-Met after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells expressing c-Met after 48 hrs by MTT assay
[PMID: 35227978]
体外研究
(In Vitro)

Antitumor agent-45 (Compound 21) enhibits IC50 values of 1.06, 10.87 and 0.11 μM in A549, Hela and MCF-7 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-45 相关抗体:
分子量

570.37

Formula

C28H17BrFN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-45 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-452581082-74-6Antitumor agent45Antitumor agent 45Apoptosisc-Met/HGFRA549apoptosiscell arrestc-MetInhibitorinhibitorinhibit

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