2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Antitumor agent-97

Antitumor agent-97 (化合物 42) 是一种抗癌剂。Antitumor agent-97 能有效抑制 MGC 803 细胞的增殖和自噬 (autophagy)，并诱导细胞凋亡 (apoptosis)。Antitumor agent-97 还能增强 MGC 803 细胞中 ROS 的积累。Antitumor agent-97 可用于癌症的研究。

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Antitumor agent-97 Chemical Structure

Antitumor agent-97 Chemical Structure

CAS No. : 2654024-16-3

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Antitumor agent-97 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-97 (compound 42) is an anticancer agent. Antitumor agent-97 can effectively inhibit the proliferation and autophagy of MGC 803 cells, and induce apoptosis. Antitumor agent-97 also enhances ROS accumulation in MGC 803 cells. Antitumor agent-97 can be used in cancer research[1].

体外研究
(In Vitro)

Antitumor agent-97 (Compound 42; 0-200 μM; 24 h) 以浓度依赖的方式抑制 MGC 803 细胞的活力，其 IC50 值为 20.921 μM[1]。
Antitumor agent-97 (20 μM; 24 h) 减少 MGC 803 细胞的增殖[1]。
Antitumor agent-97 (20 μM; 24 h) 在 MGC 803 细胞中显示出诱导细胞凋亡，并抑制细胞自噬的活性[1]。
Antitumor agent-97 (20 μM; 0-24 h) 增强 MGC 803 细胞中 ROS 的积累[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-97 相关抗体:

Cell Viability Assay[1]

Cell Line: MGC 803 cells
Concentration: 0-200 μM
Incubation Time: 24 h
Result: Suppressed cell viability (IC50 = 20.921 μM).

Cell Proliferation Assay[1]

Cell Line: MGC 803 cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Inhibited cell proliferation.

Western Blot Analysis[1]

Cell Line: MGC 803 cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Significantly upregulated the protein expression of LC3B-II and p62 and decreased the protein expression of LC3B-I.
Enhanced the protein expression of cleaved caspase-9 and cleaved caspase-3, and decreased the protein expression of B-cell lymphoma-2 (Bcl-2).
分子量

370.52

Formula

C24H34O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-97 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-972654024-16-3Antitumor agent97Antitumor agent 97ApoptosisAutophagycancertumorMGC 803 cellsROSapoptosisautophagyInhibitorinhibitorinhibit

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