2. Protein Tyrosine Kinase/RTK
  3. c-Kit
  4. AP23848

AP23848 是一种 ATP 依赖性激酶抑制剂，在体外和体内均能有效且选择性地针对 Kit 激活环突变，具有抗肿瘤活性。AP23848 在小鼠中可抑制激活环突变 Kit 的磷酸化及肿瘤生长，可用于靶向含有 D816V 突变的疾病，如系统性肥大细胞增多症 (SM) 和急性髓系白血病 (AML) 研究。

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AP23848 Chemical Structure

AP23848 Chemical Structure

CAS No. : 834894-21-2

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AP23848 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AP23848 is an ATP-dependent kinase inhibitor that effectively and selectively targets the Kit activation loop mutation both in vitro and in vivo, showing anti-tumor activity. AP23848 can inhibit the phosphorylation of the activated Kit mutation and tumor growth in mice, making it suitable for targeting diseases with the D816V mutation, such as systemic mastocytosis (SM) and acute myeloid leukemia (AML) research[1].

分子量

531.63

Formula

C30H38N5O2P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AP23848 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AP23848834894-21-2AP 23848AP-23848c-KitSCFRCD117D816Vc-kitSMAMLInhibitorinhibitorinhibit

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HY-107458
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