1. JAK/STAT Signaling Stem Cell/Wnt
  2. STAT
  3. APTSTAT3-9R

APTSTAT3-9R 是一种特定的 STAT3 结合肽,通过特异性阻断 STAT3 磷酸化来抑制 STAT3 激活和下游信号传导。APTSTAT3-9R 具有抗增殖作用和抗肿瘤活性。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

APTSTAT3-9R Chemical Structure

APTSTAT3-9R Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥1500
In-stock
5 mg ¥4500
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

MCE 顾客使用本产品发表的 1 篇科研文献

查看 STAT 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity[1].

IC50 & Target[1]

STAT3

 

体外研究
(In Vitro)

APTSTAT3-9R (7.5, 15, and 30 μmol/L; 6 hours) significantly reduces STAT3–DNA-binding activity in a dose-dependent manner in human lung carcinoma cells (A549)[1].
APTSTAT3-9R (30 μM; for 2 weeks) suppresses cell viability and proliferation of cancer cells and significantly suppresses colony formation. APTSTAT3-9R has IC50s of 10 to 20 μM in A549, B16F1 and HepG2 cells[1].
APTSTAT3-9R (7.5, 15, and 30 μmol/L; 6 hours) effectively inhibits phosphorylation of STAT3 but does not affect the level of AKT phosphorylation, indicating specificity of the aptide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

APTSTAT3-9R (8 mg/kg in 50 μL; intratumorally injected every other day for a total of four injections) suppresses tumor growth in 6-week-old female BALB/c nude mice with A549 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

4947.51

Formula

C223H330N80O51

性状

固体

颜色

White to off-white

Sequence

His-Gly-Phe-Gln-Trp-Pro-Gly-Ser-Trp-Thr-Trp-Glu-Asn-Gly-Lys-Trp-Thr-Trp-Lys-Gly-Ala-Tyr-Gln-Phe-Leu-Lys-Gly-Gly-Gly-Gly-Ser-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg

Sequence Shortening

HGFQWPGSWTWENGKWTWKGAYQFLKGGGGSRRRRRRRRR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • 储存条件中写的 under nitrogen 是什么意思呢?这个是要放在液氮吗?如果我放在 -80 ℃ 是不是不需要 under nitrogen 呢?

    under nitrogen 是要充氮气保存的意思,如果化合物容易被氧化,长期储存是建议在惰性气体(例如氮气)中储存,避免长时间接触空气。产品储存在 -80 ℃ 也是需要充氮气储存的。氮气的置换操作可以关注我们微信公众号“MCE 抑制剂”输入“氮气”,会有相关的操作指南。

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产品名称:
APTSTAT3-9R
目录号:
HY-P2282
需求量:
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