2. Anti-infection
  3. Filovirus
  4. As-358 hydrochloride

As-358 (hydrochloride) 对埃博拉病毒 (Ebola virus) 和马尔堡病毒 (Marburg virus) 具有抑制活性，IC50 分别为 9.1 μM 和 18.1 μM，同时也具有良好的体内安全性。

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As-358 hydrochloride Chemical Structure

As-358 hydrochloride Chemical Structure

CAS No. : 2374723-26-7

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Other Forms of As-358 hydrochloride:

As-358 hydrochloride 相关抗体

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查看 Filovirus 亚型特异性产品:

查看所有亚型
EBOV MARV ZEBOV

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1].

IC50 & Target

EBOV

 

MARV

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T CC50
87 μM
Compound: 3b.HCl
Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
[PMID: 32905862]
Vero CC50
279.1 μM
Compound: 3b.HCl
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
[PMID: 32905862]
体外研究
(In Vitro)

As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

As-358 hydrochloride 相关抗体:

Cell Proliferation Assay

Cell Line: Vero (infected with EBOV and MARV)[1]
Concentration: 0-500 μM
Incubation Time: 10 days
Result: Exhibits inhibitory activities against EBOV and MARV, with IC50s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively.
体内研究
(In Vivo)

As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[1]
Dosage: 1.08, 0.44, 0.27, and 0.14 g/kg
Administration: IG; single (observed for 7 days)
Result: Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg.
分子量

329.91

Formula

C18H32ClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

As-358 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

As-3582374723-26-7As358As 358FilovirusEbola virusMarburg virusLow toxicityICR miceInhibitorinhibitorinhibit

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As-358 hydrochloride
目录号：
HY-146883A
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