2. Anti-infection
  3. Filovirus
  4. As-358

As-358 对埃博拉病毒 (Ebola virus) 和马尔堡病毒 (Marburg virus) 具有抑制活性，IC50 分别为 47.5 μM 和 3.7 μM。

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As-358 Chemical Structure

As-358 Chemical Structure

CAS No. : 2222042-47-7

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Customer Review

Other Forms of As-358:

As-358 相关抗体

Top Publications Citing Use of Products

查看 Filovirus 亚型特异性产品:

查看所有亚型
EBOV MARV ZEBOV

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM[1].

IC50 & Target

EBOV

 

MARV

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 CC50
302 μM
Compound: 4
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30108738]
HEK-293T CC50
289.7 μM
Compound: 3b; As-358
Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
[PMID: 32905862]
MDCK CC50
69.6 μM
Compound: 14
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
[PMID: 30108810]
Vero CC50
442.9 μM
Compound: 3b; As-358
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
[PMID: 32905862]
体外研究
(In Vitro)

As-358 (compound 3b) (0-500 μM; 10 days) exhibits inhibitory activities against EBOV and MARV[1].
As-358 (0-100 μM; 48 hours) can inhibit WT-EboV-GP and mutant D522A-EboV-GP, with IC50s of 1.7 and 2.2 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

As-358 相关抗体:

Cell Proliferation Assay

Cell Line: Vero (infected with EBOV and MARV)[1]
Concentration: 0-500 μM
Incubation Time: 10 days
Result: Exhibited inhibitory activities against EBOV and MARV, with IC50s of 47.5 ± 8.2 μM and 3.7 ± 1.7 μM, SI values of 9 and 118, respectively.
分子量

293.44

Formula

C18H31NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

As-358 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

As-3582222042-47-7As358As 358FilovirusEbola virusMarburg virusAntiviralSelectiveInhibitorinhibitorinhibit

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产品名称：
As-358
目录号：
HY-146883
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