2. Vitamin D Related/Nuclear Receptor
  3. Progesterone Receptor
  4. Asoprisnil

Asoprisnil  (Synonyms: J867)

目录号: HY-119433 纯度: 98.30%
COA 产品使用指南 技术支持

Asoprisnil (J867) 是一种选择性孕激素受体 (progesterone receptor) 调节剂，对动物和人类中各种孕酮靶向组织具有混合的孕酮激动剂和拮抗剂作用。

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Asoprisnil Chemical Structure

Asoprisnil Chemical Structure

CAS No. : 199396-76-4

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规格 价格 是否有货 数量
1 mg ￥1700
In-stock
5 mg ￥4350
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Asoprisnil 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
COS-7 IC50
1600 nM
Compound: 5, asoprisnil
Antagonist activity at human MR ligand binding domain expressed in african green monkey COS7 cells in presence of aldosterone by Gal4 hybrid assay
Antagonist activity at human MR ligand binding domain expressed in african green monkey COS7 cells in presence of aldosterone by Gal4 hybrid assay
[PMID: 18318463]
COS-7 IC50
1900 nM
Compound: 5, asoprisnil
Antagonist activity at human ER ligand binding domain expressed in african green monkey COS7 cells in presence of 17-beta-estradiol by Gal4 hybrid assay
Antagonist activity at human ER ligand binding domain expressed in african green monkey COS7 cells in presence of 17-beta-estradiol by Gal4 hybrid assay
[PMID: 18318463]
COS-7 IC50
6.1 nM
Compound: 5, asoprisnil
Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4 hybrid assay
Antagonist activity at human AR ligand binding domain expressed in african green monkey COS7 cells in presence of 5-alpha-dihydrotestosterone by Gal4 hybrid assay
[PMID: 18318463]
COS-7 IC50
85 nM
Compound: 5, asoprisnil
Antagonist activity at human GR ligand binding domain expressed in african green monkey COS7 cells in presence of Dexamethasone by Gal4 hybrid assay
Antagonist activity at human GR ligand binding domain expressed in african green monkey COS7 cells in presence of Dexamethasone by Gal4 hybrid assay
[PMID: 18318463]
T47D IC50
0.3 nM
Compound: 2
Antagonist activity against progesterone receptor in human T47D cells by alkaline phosphatase assay
Antagonist activity against progesterone receptor in human T47D cells by alkaline phosphatase assay
[PMID: 23079530]
Clinical Trial
分子量

449.58

Formula

C28H35NO4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 45 mg/mL (100.09 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2243 mL 11.1215 mL 22.2430 mL
5 mM 0.4449 mL 2.2243 mL 4.4486 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.30%

COA (197 KB) LCMS (151 KB)

产品使用指南 (1538 KB)
参考文献

Asoprisnil 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2243 mL 11.1215 mL 22.2430 mL 55.6075 mL
5 mM 0.4449 mL 2.2243 mL 4.4486 mL 11.1215 mL
10 mM 0.2224 mL 1.1121 mL 2.2243 mL 5.5607 mL
15 mM 0.1483 mL 0.7414 mL 1.4829 mL 3.7072 mL
20 mM 0.1112 mL 0.5561 mL 1.1121 mL 2.7804 mL
25 mM 0.0890 mL 0.4449 mL 0.8897 mL 2.2243 mL
30 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8536 mL
40 mM 0.0556 mL 0.2780 mL 0.5561 mL 1.3902 mL
50 mM 0.0445 mL 0.2224 mL 0.4449 mL 1.1121 mL
60 mM 0.0371 mL 0.1854 mL 0.3707 mL 0.9268 mL
80 mM 0.0278 mL 0.1390 mL 0.2780 mL 0.6951 mL
100 mM 0.0222 mL 0.1112 mL 0.2224 mL 0.5561 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asoprisnil199396-76-4J867J 867J-867Progesterone ReceptorNR3C3Inhibitorinhibitorinhibit

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目录号：
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